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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	P2Y purinoceptor 4
Species	Rattus norvegicus (Rat)
Gene	P2ry4
Synonym	UNR pyrimidinoceptor pyrimidinergic receptor P2Y P2Y4R P2Y4 receptor P2Y4 P2Y purinoceptor 4 P2Y ATP receptor 4 NRU uridine nucleotide receptor [ Show all ]
Disease	N/A for non-human GPCRs
Length	361
Amino acid sequence	MTSAESLLFTSLGPSPSSGDGDCRFNEEFKFILLPMSYAVVFVLGLALNAPTLWLFLFRLRPWDATATYMFHLALSDTLYVLSLPTLVYYYAARNHWPFGTGLCKFVRFLFYWNLYCSVLFLTCISVHRYLGICHPLRAIRWGRPRFASLLCLGVWLVVAGCLVPNLFFVTTNANGTTILCHDTTLPEEFDHYVYFSSAVMVLLFGLPFLITLVCYGLMARRLYRPLPGAGQSSSRLRSLRTIAVVLTVFAVCFVPFHITRTIYYQARLLQADCHVLNIVNVVYKVTRPLASANSCLDPVLYLFTGDKYRNQLQQLCRGSKPKPRTAASSLALVTLHEESISRWADTHQDSTFSAYEGDRL
UniProt	O35811
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2124
IUPHAR	325
DrugBank	N/A

Ligand

Name	Cytidine triphosphate
Molecular formula	C9H16N3O14P3
IUPAC name	[[(2R,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate
Molecular weight	483.155
Hydrogen bond acceptor	14
Hydrogen bond donor	7
XlogP	-5.6
Synonyms	5'-CTP bmse000277 Cystetine Triphosphate Cytidine mono Cytidine-5'-triphosphate disodium salt dihydrate GTPL1741 SCHEMBL104629 1259312-99-6 1wvc 81012-87-5 C9H16N3O14P3 Cytidine 5'-(tetrahydrogen triphosphate) (8CI,9CI) CYTIDINE, 5'-(TETRAHYDROGEN TRIPHOSPHATE) D00PQC K0118UX80T [(2R,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl (hydroxy-phosphonooxyphosphoryl) hydrogen phosphate 4-25-00-03676 (Beilstein Handbook Reference) AN-25480 CTK5E8385 Cytidine 5'-triphosphoric acid cytidine-5'-triphosphate EINECS 200-611-4 MolPort-009-198-566 [[[(2R,3S,4R,5R)-5-(4-Amino-2-oxo-pyrimidin-1-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxyphosphonic acid 065C474 5'-CYTIDYLATE TRIPHOSPHATE BRN 0071190 Cytidine 3'-triphosphate Cytidine mono(tetrahydrogen triphosphate) (ester) Cytidine-5'-triphosphate, 100MM Solution H4ctp UNII-K0118UX80T 1613528-28-1 2(1H)-Pyrimidinone, 4-amino-1-[5-O-[hydroxy[[hydroxy(phosphonooxy)phosphinyl]oxy]phosphinyl]-.beta.-D-ribofuranosyl]- AC1L1LYC CHEBI:17677 Cytidine 5'-triphosphate Cytidine, mono(tetrahydrogen triphosphate) (ester) DB02431 KB-251306 [[(2R,3S,4R,5R)-5-(4-amino-2-oxo-pyrimidin-1-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl] phosphono hydrogen phosphate ((2R,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl tetrahydrogen triphosphate 5'-(tetrahydrogen triphosphate) cytidine AX8042590 CTP Cytidine 5-Prime-Triphosphate Cytidine-5'-triphosphate disodium salt FT-0601271 SC-17096 123334-07-6 65-47-4 C00063 Cytidine 5'-(tetrahydrogen triphosphate) Cytidine5'-(tetrahydrogen triphosphate) I14-92079 ZINC3861746 2ad5 AJ-75351 CHEMBL223533 cytidine 5'-triphosphate, disodium salt hydrate Cytidine-5 inverted exclamation mark -triphosphate Deoxycytosine triphosphate LS-59081 [[(2R,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate ({[({[(2R,3S,4R,5R)-5-(4-amino-2-oxo-1,2-dihydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)phosphonic acid [ Show all ]
Inchi Key	PCDQPRRSZKQHHS-XVFCMESISA-N
Inchi ID	InChI=1S/C9H16N3O14P3/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18)/t4-,6-,7-,8-/m1/s1
PubChem CID	6176
ChEMBL	N/A
IUPHAR	1741
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has more than 5 hydrogen bond donor. This ligand has more than 10 hydrogen bond acceptor.

Experimental Data

Parameter	Value	Reference	Database source
EC50	7943.28 nM	PMID10779375	IUPHAR

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