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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Lysophosphatidic acid receptor 1
Species	Mus musculus (Mouse)
Gene	Lpar1
Synonym	VZG-1 {ECO:0000303\|PubMed:8922387, ECO:0000303\|PubMed:9600933} Rec1.3 {ECO:0000303\|PubMed:9013780} Lysophosphatidic acid receptor Edg-2 {ECO:0000303\|PubMed:9600933} lysophosphatidic acid receptor Edg-2 Lpar1 LPA1 receptor LPA-1 {ECO:0000303\|PubMed:9600933, ECO:0000303\|PubMed:9721207} LPA receptor 1 {ECO:0000305} LPA receptor 1 GPR26 endothelial differentiation gene 2, lysophosphatidic acid G-protein-coupled receptor, 2 EDG2 VZG1 [ Show all ]
Disease	N/A for non-human GPCRs
Length	364
Amino acid sequence	MAAASTSSPVISQPQFTAMNEQQCFYNESIAFFYNRSGKYLATEWNTVSKLVMGLGITVCVFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLIDTSLTASVANLLAIAIERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIDHCSNMAPLYSDSYLVFWAIFNLVTFVVMVVLYAHIFGYVRQRTMRMSRHSSGPRRNRDTMMSLLKTVVIVLGAFIVCWTPGLVLLLLDVCCPQCDVLAYEKFFLLLAEFNSAMNPIIYSYRDKEMSATFRQILCCQRNENPNGPTEGSDRSASSLNHTILAGVHSNDHSVV
UniProt	P61793
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3621025
IUPHAR	272
DrugBank	N/A

Ligand

Name	CHEMBL327240
Molecular formula	C34H52NO6P
IUPAC name	[(2R)-2-[[(Z)-octadec-9-enoyl]amino]-3-(4-phenylmethoxyphenyl)propyl] dihydrogen phosphate
Molecular weight	601.765
Hydrogen bond acceptor	6
Hydrogen bond donor	3
XlogP	8.7
Synonyms	[(2R)-2-[[(Z)-octadec-9-enoyl]amino]-3-[4-(phenylmethoxy)phenyl]propyl] dihydrogen phosphate Phosphoric acid mono-[(R)-3-(4-benzyloxy-phenyl)-2-((Z)-octadec-9-enoylamino)-propyl] ester VPC-12249 BDBM50146254 D0PI4H SCHEMBL13109873 VPC12249 GTPL2909 VPC 12249 [ Show all ]
Inchi Key	NJLPYJKKKSBCSK-MJPIYRIWSA-N
Inchi ID	InChI=1S/C34H52NO6P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-19-22-34(36)35-32(29-41-42(37,38)39)27-30-23-25-33(26-24-30)40-28-31-20-17-16-18-21-31/h9-10,16-18,20-21,23-26,32H,2-8,11-15,19,22,27-29H2,1H3,(H,35,36)(H2,37,38,39)/b10-9-/t32-/m1/s1
PubChem CID	10282223
ChEMBL	CHEMBL327240
IUPHAR	2909
BindingDB	50146254
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
Ki	137.0 - 5700.0 nM	PMID11723223	IUPHAR

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