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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Hydroxycarboxylic acid receptor 3
Species	Homo sapiens (Human)
Gene	HCAR3
Synonym	G-protein coupled receptor 109B Nicotinic acid receptor 2 Nic2 NIACR2 Niacin receptor 2 Low affinity nicotinic acid receptor G protein-coupled receptor 109B G-protein coupled receptor HM74B G-protein coupled receptor HM74 HCA3 receptor [ Show all ]
Disease	N/A
Length	387
Amino acid sequence	MNRHHLQDHFLEIDKKNCCVFRDDFIAKVLPPVLGLEFIFGLLGNGLALWIFCFHLKSWKSSRIFLFNLAVADFLLIICLPFVMDYYVRRSDWKFGDIPCRLVLFMFAMNRQGSIIFLTVVAVDRYFRVVHPHHALNKISNWTAAIISCLLWGITVGLTVHLLKKKLLIQNGTANVCISFSICHTFRWHEAMFLLEFFLPLGIILFCSARIIWSLRQRQMDRHAKIKRAITFIMVVAIVFVICFLPSVVVRIHIFWLLHTSGTQNCEVYRSVDLAFFITLSFTYMNSMLDPVVYYFSSPSFPNFFSTLINRCLQRKITGEPDNNRSTSVELTGDPNKTRGAPEALIANSGEPWSPSYLGPTSNNHSKKGHCHQEPASLEKQLGCCIE
UniProt	P49019
Protein Data Bank	N/A
GPCR-HGmod model	P49019
3D structure model	This predicted structure model is from GPCR-EXP P49019.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4421
IUPHAR	313
DrugBank	BE0000836

Ligand

Name	(3S)-3-hydroxyoctanoic acid
Molecular formula	C8H16O3
IUPAC name	(3S)-3-hydroxyoctanoic acid
Molecular weight	160.213
Hydrogen bond acceptor	3
Hydrogen bond donor	2
XlogP	1.4
Synonyms	(S)-3-hydroxycaprylic acid CHEBI:37100 MolPort-028-951-619 ZINC2019242 (S)-3-OH-caprylic acid 3-OH-octanoic acid DTXSID10463642 Octanoic acid, 3-hydroxy-, L- (3S)-3-hydroxy-octanoic acid (S)-beta-OH-caprylic acid 3S-hydroxyoctanoic acid KS-00002BH4 UNII-8M44B02CSJ component NDPLAKGOSZHTPH-ZETCQYMHSA-N (S)-3-hydroxyoctanoic acid 3-Hydroxyoctanoic acid, (+)- CTK1B8166 Octanoic acid, 3-hydroxy-, (3S)- (S)-beta-hydroxycaprylic acid 33796-86-0 GTPL2933 SCHEMBL6240298 (S)-beta-OH-octanoic acid AKOS026730467 LMFA01050433 UNII-KJR5TU7HW6 (S)-3-OH octanoic acid 3-Hydroxyoctanoic acid, (S)- D00FTQ Octanoic acid, 3-hydroxy-, (S)- (S)-beta-hydroxyoctanoic acid 3HO KJR5TU7HW6 SS-4992 [ Show all ]
Inchi Key	NDPLAKGOSZHTPH-ZETCQYMHSA-N
Inchi ID	InChI=1S/C8H16O3/c1-2-3-4-5-7(9)6-8(10)11/h7,9H,2-6H2,1H3,(H,10,11)/t7-/m0/s1
PubChem CID	11367166
ChEMBL	N/A
IUPHAR	2933
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	8000.0 nM	PMID19561068	IUPHAR

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