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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	P2Y purinoceptor 4
Species	Rattus norvegicus (Rat)
Gene	P2ry4
Synonym	UNR pyrimidinoceptor pyrimidinergic receptor P2Y P2Y4R P2Y4 receptor P2Y4 P2Y purinoceptor 4 P2Y ATP receptor 4 NRU uridine nucleotide receptor [ Show all ]
Disease	N/A for non-human GPCRs
Length	361
Amino acid sequence	MTSAESLLFTSLGPSPSSGDGDCRFNEEFKFILLPMSYAVVFVLGLALNAPTLWLFLFRLRPWDATATYMFHLALSDTLYVLSLPTLVYYYAARNHWPFGTGLCKFVRFLFYWNLYCSVLFLTCISVHRYLGICHPLRAIRWGRPRFASLLCLGVWLVVAGCLVPNLFFVTTNANGTTILCHDTTLPEEFDHYVYFSSAVMVLLFGLPFLITLVCYGLMARRLYRPLPGAGQSSSRLRSLRTIAVVLTVFAVCFVPFHITRTIYYQARLLQADCHVLNIVNVVYKVTRPLASANSCLDPVLYLFTGDKYRNQLQQLCRGSKPKPRTAASSLALVTLHEESISRWADTHQDSTFSAYEGDRL
UniProt	O35811
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2124
IUPHAR	325
DrugBank	N/A

Ligand

Name	inosine triphosphate
Molecular formula	C10H15N4O14P3
IUPAC name	[[(2R,3S,4R,5R)-3,4-dihydroxy-5-(6-oxo-1H-purin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate
Molecular weight	508.165
Hydrogen bond acceptor	16
Hydrogen bond donor	7
XlogP	-5.1
Synonyms	CHEBI:16039 Inosine 5'-(tetrahydrogen triphosphate) (8CI,9CI) ITT 212A76R77X AC1L1RAP DTXSID8074499 Inosine 5-triphopshate SCHEMBL163281 bmse000255 Inosine 5 Inosine-5'-Triphosphate [(2R,3S,4R,5R)-3,4-dihydroxy-5-(6-oxo-3H-purin-9-yl)oxolan-2-yl]methyl (hydroxy-phosphonooxyphosphoryl) hydrogen phosphate CHEMBL1233686 Inosine 5'-triphosphate LS-84004 5'-ITP AC1Q6S2R EINECS 205-046-7 UNII-212A76R77X ({[({[(2R,3S,4R,5R)-3,4-dihydroxy-5-(6-hydroxy-9H-purin-9-yl)oxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)phosphonic acid C00081 Inosine 5'-(tetrahydrogen triphosphate) ITP [[(2R,3S,4R,5R)-3,4-dihydroxy-5-(6-oxo-3H-purin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate 2'-inosine-5'-triphosphate D00WOK Inosine 5(tetrahydrogen triphosphate) O(5')-(tetrahydroxytriphosphoryl)inosine 5-ITP AJ-57364 GTPL1743 Inosine tripolyphosphate ZINC8215530 132-06-9 [ Show all ]
Inchi Key	HAEJPQIATWHALX-KQYNXXCUSA-N
Inchi ID	InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1
PubChem CID	135398643
ChEMBL	N/A
IUPHAR	1743
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has more than 5 hydrogen bond donor. This ligand has more than 10 hydrogen bond acceptor. This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
EC50	1584.89 - 1995.26 nM	PMID9647463, PMID10779375	IUPHAR

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