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GLASS

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GPCR

Name	Prostaglandin E2 receptor EP4 subtype
Species	Rattus norvegicus (Rat)
Gene	Ptger4
Synonym	EP2 EP4 receptor PGE receptor EP4 subtype PGE2 receptor EP4 subtype Prostanoid EP4 receptor
Disease	N/A for non-human GPCRs
Length	488
Amino acid sequence	MSIPGVNASFSSTPERLNSPVTIPAVMFIFGVVGNLVAIVVLCKSRKEQKETTFYTLVCGLAVTDLLGTLLVSPVTIATYMKGQWPGDQALCDYSTFILLFFGLSGLSIICAMSIERYLAINHAYFYSHYVDKRLAGLTLFAVYASNVLFCALPNMGLGRSERQYPGTWCFIDWTTNVTAYAAFSYMYAGFSSFLILATVLCNVLVCGALLRMLRQFMRRTSLGTEQHHAAAAAAVASVACRGHAAASPALQRLSDFRRRRSFRRIAGAEIQMVILLIATSLVVLICSIPLVVRVFINQLYQPSVVKDISRNPDLQAIRIASVNPILDPWIYILLRKTVLSKAIEKIKCLFCRIGGSGRDGSAQHCSESRRTSSAMSGHSRSFLSRELREISSTSHTLLYLPDLTESSLGGKNLLPGTHGMGLTQADTTSLRTLRISETSDSSQGQDSESVLLVDEVSGSQREEPASKGNSLQVTFPSETLKLSEKCI
UniProt	P43114
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4086
IUPHAR	343
DrugBank	N/A

Ligand

Name	alprostadil
Molecular formula	C20H34O5
IUPAC name	7-[(1R,2R,3R)-3-hydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]-5-oxocyclopentyl]heptanoic acid
Molecular weight	354.487
Hydrogen bond acceptor	5
Hydrogen bond donor	3
XlogP	3.2
Synonyms	Alprostadil(Caverject) MLS001424250 Prostaglandin E1 AS-16360 NCGC00025234-02 Prostaglandin-E1 BG0025 RayVa BSPBio_001488 (11?,13E,15S)-11,15-Dihydroxy-9-oxo-prost-13-en-1-oic acid SMR000112594 (13e)-(15s)-11alpha,15-dihydroxy-9-oxoprost-13-enoic acid Sugiran D0N2EF Vasaprostan EINECS 212-017-2 7-((1R,2R,3R)-3-hydroxy-2-((S,E)-3-hydroxyoct-1-en-1-yl)-5-oxocyclopentyl)heptanoic acid HMS1361K10 AB0014134 HMS3402K10 AI3-62116 l-Prostaglandin E1 Prestwick2_001018 Prink (TN) Alprostadil, meets USP testing specifications MR-256 Prostaglandin E1, >=99.0% (TLC) BCP01740 NCGC00025234-05 Prostavasin BPBio1_001293 (+)-3-hydroxy-2-(3-hydroxy-1-octenyl)-5-oxo-Cyclopentaneheptanoate SAM001246840 Caverject (13E)-(15S)-11,15-dihydroxy-9-oxoprost-13-enoate SR-01000597593-5 CS-1905 11,15-Dihydroxy-9-oxoprost-13-en-1-oate Tox21_110482 DSSTox_GSID_22578 3-Hydroxy-2-(3-hydroxy-1-octenyl)-5-oxo-cyclopentaneheptanoic acid Vitaros (TN) FemLife 7-[(1r,3r)-3-Hydroxy-2-[(1e,3s)-3-Hydroxyoct-1-En-1-Yl]-5-Oxocyclopentyl]heptanoic Acid HMS1989K10 AB00514004-08 HY-B0131 PGE1 Liprostin Minprog Prost-13-en-1-oic acid, 11,15-dihydroxy-9-oxo-, (11alpha,13E,15S)- Alprostadilum [INN-Latin] NC00438 Prostaglandin E1; PGE1 Befar Prostin VR pediatric (TN) BRD-K52459643-001-17-7 (-)-3-hydroxy-2-(3-hydroxy-1-octenyl)-5-oxo-Cyclopentaneheptanoic acid SCHEMBL33317 CCG-101188 (13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprost-13-enoic acid SR-01000946253-1 D00180 119314-69-1 U-10136 Edex ZINC3813088 GTPL1882 745P653 HMS2098K17 AC-6095 l-3-Hydroxy-2-(3-hydroxy-1-octenyl)-5-oxocyclopentaneheptanoic acid PGE1;Prostaglandin E1 Alprostadil Prostoglandin E1 Alprostadil(usan) MolPort-003-939-183 Prostaglandin E1, 98+% B2154 NCGC00025234-03 Prostaglandine E BIDD:GT0747 RP17688 C04741 (11alpha,13E,15S)-11,15-dihydroxy-9-oxoprost-13-en-1-oic acid SR-01000597593 CHEMBL495 (13E,15S)-11alpha,15-dihydroxy-9-oxoprost-13-en-1-oic acid SYN3025 22299-37-2 Viridal EX-A1411 7-((1R,2R,3R)-3-hydroxy-2-((S,E)-3-hydroxyoct-1-enyl)-5-oxocyclopentyl)heptanoic acid HMS1571K17 AB00514004 HMS3648O17 AKOS015961103 Lipo-alprostadil Prestwick3_001018 LMFA03010134 Promostan Alprostadil, United States Pharmacopeia (USP) Reference Standard Muse Prostaglandin E1, powder, gamma-irradiated, BioXtra, suitable for cell culture BCP9000277 NSC 165559 Prostin VR BRD-K52459643-001-06-0 (+)-3-hydroxy-2-(3-hydroxy-1-octenyl)-5-oxo-Cyclopentaneheptanoic acid SAM001246845 Caverject (TN) (13E)-(15S)-11,15-dihydroxy-9-oxoprost-13-enoic acid SR-01000597593-6 Cyclopentaneheptanoic acid, 3-hydroxy-2-(3-hydroxy-1-octenyl)-5-oxo-, (-)- 11,15-Dihydroxy-9-oxoprost-13-en-1-oic acid U 10136 DSSTox_RID_76640 3-Hydroxy-2-(3-hydroxy-1-octenyl)-5-oxocyclopentaneheptanoic acid W-104416 Femprox 7-[5-((1E)(3S)-3-hydroxyoct-1-enyl)(1R,4R,5R)-4-hydroxy-2-oxocyclopentyl]hepta noic acid HMS2052L11 AB00514004_09 IDI1_033958 PGE1 Oligomer Alprostadil (JP15/USP/INN) MLS000758964 Prost-13-en-1-oic acid, 11,15-dihydroxy-9-oxo-, (11alpha,13E,15S)-, homopolymer Alprox-TD NCGC00016535-01 Prostaglandin E1;Edex;Muse;Liprostin;Caverject Befar (TN) Prostivas BSPBio_001175 (-)-Protaglandin E1 SMP2_000271 CHEBI:15544 (13E)-(15S)-11alpha,15-Dihydroxy-9-oxoprost-13-enoate ST50826271 D0I4DQ 11alpha,15alpha-Dihydroxy-9-oxo-13-trans-prostenoic acid UNII-F5TD010360 Edex (TN) 50865-30-0 HEI-507 9-oxo-11R,15S-dihydroxy-13E-prostaenoic acid HMS3268I09 AC1NQXHQ l-PGE1 PGE1alpha Alprostadil [USAN:USP:INN:BAN:JAN] Prink Alprostadil, European Pharmacopoeia (EP) Reference Standard MR 256 Prostaglandin E1, >=98% (HPLC), synthetic BC205461 NCGC00025234-04 Prostandin BML1-F06 s1508 CAS-745-65-3 (11alpha,13E,15S)-11,15-Dihydroxy-9-oxoprost-13-enoic acid SR-01000597593-1 CPD000112594 (1R,2R,3R)-3-Hydroxy-2-((E)-(3S)-3-hydroxy-1-octenyl)-5-oxocyclopentaneheptanoic acid Topiglan DSSTox_CID_2578 3-Hydroxy-2-(3-hydroxy-1-octenyl)-5-oxo-cyclopentaneheptanoate Vitaros F5TD010360 7-[(1R,2R,3R)-3-hydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]-5-oxocyclopentyl]heptanoic acid HMS1791K10 AB00514004-06 HMS3715K17 PGE-1 Alista Lipoprost MFCD00077860 Prost-13-en-1-oic acid, 11,15-dihydroxy-9-oxo-, (11.alpha.,13E,15S)- Alprostadilum Muse (TN) Prostaglandin E1, synthetic, powder, BioReagent, suitable for cell culture BDBM50101853 ONO 1608 Prostin VR Pediatric BRD-K52459643-001-10-2 (-)-3-hydroxy-2-(3-hydroxy-1-octenyl)-5-oxo-Cyclopentaneheptanoate SAM001247093 Caverject Impulse (13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprost-13-enoate SR-01000946253 Cyclopentaneheptanoic acid, 3-hydroxy-2-(3-hydroxy-1-octenyl)-5-oxo-, l- 11,15-dihydroxy-9-oxoprost-13-en-1-oic acid (ACD/Name 4.0) U-10,136 DTXSID9022578 50-83-9 XPG GMVPRGQOIOIIMI-DWKJAMRDSA-N 745-65-3 HMS2090L08 AB2000131 K274 PGE1, Prostaglandin E1, powder Alprostadil (JP17/USP/INN) [ Show all ]
Inchi Key	GMVPRGQOIOIIMI-DWKJAMRDSA-N
Inchi ID	InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,19+/m0/s1
PubChem CID	5280723
ChEMBL	CHEMBL495
IUPHAR	1882
BindingDB	50101853
DrugBank	DB00770
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	0.630957 nM	PMID9537820	IUPHAR

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