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GPCR

Name	Trace amine-associated receptor 1
Species	Mus musculus (Mouse)
Gene	Taar1
Synonym	TA1 receptor TaR-1 TAR1 trace amine receptor 1 TRAR1
Disease	N/A for non-human GPCRs
Length	332
Amino acid sequence	MHLCHAITNISHRNSDWSREVQASLYSLMSLIILATLVGNLIVIISISHFKQLHTPTNWLLHSMAIVDFLLGCLIMPCSMVRTVERCWYFGEILCKVHTSTDIMLSSASIFHLAFISIDRYCAVCDPLRYKAKINISTILVMILVSWSLPAVYAFGMIFLELNLKGVEELYRSQVSDLGGCSPFFSKVSGVLAFMTSFYIPGSVMLFVYYRIYFIAKGQARSINRTNVQVGLEGKSQAPQSKETKAAKTLGIMVGVFLVCWCPFFLCTVLDPFLGYVIPPSLNDALYWFGYLNSALNPMVYAFFYPWFRRALKMVLLGKIFQKDSSRSKLFL
UniProt	Q923Y8
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4908
IUPHAR	364
DrugBank	N/A

Ligand

Name	tyramine
Molecular formula	C8H11NO
IUPAC name	4-(2-aminoethyl)phenol
Molecular weight	137.182
Hydrogen bond acceptor	2
Hydrogen bond donor	2
XlogP	1.1
Synonyms	51T672 Tox21_110282_1 M-3365 AEF Tyramine, 99% NCGC00016011-03 ANW-31318 WLN: Z2R DQ NCGC00016011-11 BIDD:ER0507 NCGC00063825-08 BRN 1099914 p-(2-Aminoethyl)phenol cid_5610 p-Hydroxyphenethylamine DSSTox_GSID_43874 2-(4-hydroxyphenyl)ethanamine SC-15191 HMS1923C19 Spectrum4_001801 KB-204477 4-Hydroxy phenylethylamine SY002127 KBioSS_001693 L-Tyramine AB00051887-15 Tyramin MFCD00149002 AKOS000156022 Tyramine, Vetec(TM) reagent grade, 99% NCGC00016011-06 BBL027695 [3H]-Tyramine NCGC00016011-16 bmse000870 NSC-249188 CAS-51-67-2 p-Hydroxy-.beta.-phenethylamine P-hydroxy-b-phenethylamine D01VFT .alpha.-(4-Hydroxyphenyl)-.beta.-aminoethane para-Tyramine DZGWFCGJZKJUFP-UHFFFAOYSA-N SMR000059295 HSDB 2132 4-(2-aminoethyl)-Phenol SR-01000075365 KBio2_001693 4-hydroxy-Benzeneethanamine T-8911 4-Hydroxyphenylethylamine Tocosine LS-103895 AC1Q54AZ Tyramine, 97% NCGC00016011-01 AM20060645 UNII-X8ZC7V0OX3 NCGC00016011-09 beta-(4-Hydroxyphenyl)ethylamine NCGC00063825-06 BR-47332 Oprea1_294339 p-Hydroxy-beta-phenylethylamine DivK1c_000918 2-(4-hydroxy-phenyl)ethylamine Phenol, p-(2-aminoethyl)- GTPL2148 21758-EP2298312A1 Spectrum2_000738 IDI1_000918 4-13-00-01788 (Beilstein Handbook Reference) ST51037693 KBio3_001665 a-(4-Hydroxyphenyl)-b-aminoethane to_000085 MCULE-3986856320 AJ-08146 Tyramine, analytical standard NCGC00016011-04 AS-11671 X8ZC7V0OX3 NCGC00016011-12 Biomol-NT_000075 NINDS_000918 BSPBio_002445 p-.beta.-Aminoethylphenol CS-W007606 p-Hydroxyphenylethylamine DSSTox_RID_80079 2-(4-Hydroxyphenyl)ethylamine SCHEMBL4111 HMS2235J05 4- (2-aminoethyl)-Phenol Spectrum5_000501 KB-62189 4-Hydroxy-.beta.-phenylethylamine Systogene KS-00000NMU TC-060462 Lopac-T-2879 AB0010532 MLS000079096 alpha-(4-Hydroxyphenyl)-beta-aminoethane Tyramine;4-(2-Amino-ethyl)-phenol NCGC00016011-07 BDBM29135 [3H]tyramine NCGC00063825-04 bmse000891 NSC249188 CCG-39684 p-Hydroxy-.beta.-phenylethylamine P-hydroxy-b-phenylethylamine D0C5RZ .beta.-(4-Hydroxyphenyl)ethylamine Phenethylamine, p-hydroxy- EINECS 200-115-8 SPBio_000696 HY-W007606 4-(2-Aminoethyl)-phenol(thyramin) SR-01000075365-5 KBio2_004261 4-Hydroxy-beta-phenylethylamine 51-67-2 Tox21_110282 LS-103913 ACMC-1AQH1 Tyramine, 98%, FG NCGC00016011-02 AN-41614 Uteramine NCGC00016011-10 beta-Hydroxyphenylethylamine NCGC00063825-07 BRD-K53893978-001-03-1 p-(2-aminoethyl)-Phenol CHEMBL11608 p-hydroxy-phenylethylamine DSSTox_CID_23874 2-(4-Hydroxyphenyl)-ethylamine RTC-060462 GTPL2150 21758-EP2314571A2 Spectrum3_000693 InChI=1/C8H11NO/c9-6-5-7-1-3-8(10)4-2-7/h1-4,10H,5-6,9H 4-aminoethylphenol STK531130 KBioGR_002405 KSC269I3J A0302 TRA0098101 MFCD00008193 AK-47332 Tyramine, free base NCGC00016011-05 b-(4-Hydroxyphenyl)ethylamine ZINC2233 NCGC00016011-14 bmse000243 NSC 249188 C00483 p-beta-Aminoethylphenol CTK1G9434 (4-hydroxyphenyl)ethylamine p-Tyramine DTXSID2043874 2-(p-Hydroxyphenyl)ethylamine SGCUT00017 HMS502N20 4-(2-amino-ethyl)-phenol Spectrum_001213 KBio1_000918 4-Hydroxy-b-phenylethylamine T-8910 Tenosin-wirkstoff Lopac0_001136 AC1L1KQE Tyramine base MolPort-000-698-914 alpha.-(4-Hydroxyphenyl)-beta-aminoethane Tyrosamine NCGC00016011-08 Benzeneethanamine, 4-hydroxy- NCGC00063825-05 BPBio1_001394 Opera_ID_887 CHEBI:15760 p-Hydroxy-beta-phenethylamine DB08841 2-(4'-Hydroxyphenyl)ethylamine Phenol, 4-(2-aminoethyl)- FT-0651978 21758-EP2281563A1 SPECTRUM210400 I01-2032 4-(2-Aminoethyl)phenol ST24033343 KBio2_006829 4-Hydroxyphenethylamine [ Show all ]
Inchi Key	DZGWFCGJZKJUFP-UHFFFAOYSA-N
Inchi ID	InChI=1S/C8H11NO/c9-6-5-7-1-3-8(10)4-2-7/h1-4,10H,5-6,9H2
PubChem CID	5610
ChEMBL	CHEMBL11608
IUPHAR	2148, 2150
BindingDB	29135
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	79.4328 - 630.957 nM	PMID17218486, PMID17212650, PMID19892733, PMID19725810	IUPHAR
Ki	404.0 nM	PMID19892733	IUPHAR

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