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GPCR

NameGalanin receptor type 2
SpeciesRattus norvegicus (Rat)
GeneGalr2
SynonymGAL2 receptor
GAL2-R
GALNR2
GALR-2
DiseaseN/A for non-human GPCRs
Length372
Amino acid sequenceMNGSGSQGAENTSQEGGSGGWQPEAVLVPLFFALIFLVGTVGNALVLAVLLRGGQAVSTTNLFILNLGVADLCFILCCVPFQATIYTLDDWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLALLFSGPYLSYYRQSQLANLTVCHPAWSAPRRRAMDLCTFVFSYLLPVLVLSLTYARTLRYLWRTVDPVTAGSGSQRAKRKVTRMIIIVAVLFCLCWMPHHALILCVWFGRFPLTRATYALRILSHLVSYANSCVNPIVYALVSKHFRKGFRKICAGLLRPAPRRASGRVSILAPGNHSGSMLEQESTDLTQVSEAAGPLVPPPALPNCTASSRTLDPAC
UniProtO08726
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL5577
IUPHAR244
DrugBankN/A

Ligand

NameCYM-2503
Molecular formulaC44H55N5O7
IUPAC nametert-butyl N-[(4S)-4-[[(2S)-2-(9,9a-dihydro-4aH-fluoren-9-ylmethoxycarbonylamino)-3-cyclohexylpropanoyl]amino]-5-[(4-methyl-2-oxo-1H-quinolin-7-yl)amino]-5-oxopentyl]carbamate
Molecular weight765.952
Hydrogen bond acceptor7
Hydrogen bond donor5
XlogP7.1
Synonymstert-butyl N-[(4S)-4-[(2S)-2-{[(9,9a-dihydro-4aH-fluoren-9-ylmethoxy)carbonyl]amino}-3-cyclohexylpropanamido]-4-[(4-methyl-2-oxo-1,2-dihydroquinolin-7-yl)carbamoyl]butyl]carbamate
D0E7BU
GTPL8547
Inchi KeyDSRPDMJWEFCXMI-GHKFOJCISA-N
Inchi IDInChI=1S/C44H55N5O7/c1-27-23-39(50)47-37-25-29(20-21-30(27)37)46-40(51)36(19-12-22-45-42(53)56-44(2,3)4)48-41(52)38(24-28-13-6-5-7-14-28)49-43(54)55-26-35-33-17-10-8-15-31(33)32-16-9-11-18-34(32)35/h8-11,15-18,20-21,23,25,28,31,33,35-36,38H,5-7,12-14,19,22,24,26H2,1-4H3,(H,45,53)(H,46,51)(H,47,50)(H,48,52)(H,49,54)/t31?,33?,35?,36-,38-/m0/s1
PubChem CID91827369
ChEMBLN/A
IUPHAR8547
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.
This ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
EC500.69 nMPMID20660766IUPHAR

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