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Name | C-C chemokine receptor type 10 |
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Species | Homo sapiens (Human) |
Gene | CCR10 |
Synonym | CCR-10 CCR10 CC-CKR-10 G-protein coupled receptor 2 GPR-2 [ Show all ] |
Disease | Inflammatory disease |
Length | 362 |
Amino acid sequence | MGTEATEQVSWGHYSGDEEDAYSAEPLPELCYKADVQAFSRAFQPSVSLTVAALGLAGNGLVLATHLAARRAARSPTSAHLLQLALADLLLALTLPFAAAGALQGWSLGSATCRTISGLYSASFHAGFLFLACISADRYVAIARALPAGPRPSTPGRAHLVSVIVWLLSLLLALPALLFSQDGQREGQRRCRLIFPEGLTQTVKGASAVAQVALGFALPLGVMVACYALLGRTLLAARGPERRRALRVVVALVAAFVVLQLPYSLALLLDTADLLAARERSCPASKRKDVALLVTSGLALARCGLNPVLYAFLGLRFRQDLRRLLRGGSCPSGPQPRRGCPRRPRLSSCSAPTETHSLSWDN |
UniProt | P46092 |
Protein Data Bank | N/A |
GPCR-HGmod model | P46092 |
3D structure model | This predicted structure model is from GPCR-EXP P46092. |
BioLiP | N/A |
Therapeutic Target Database | T71054 |
ChEMBL | CHEMBL2321628 |
IUPHAR | 67 |
DrugBank | N/A |
Name | eut-22 |
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Molecular formula | C23H27N5O3S |
IUPAC name | N-[(2R)-4-(2-cyanopyrrol-1-yl)-1-(4-methylpiperidin-1-yl)-1-oxobutan-2-yl]-1H-indole-4-sulfonamide |
Molecular weight | 453.561 |
Hydrogen bond acceptor | 5 |
Hydrogen bond donor | 2 |
XlogP | 2.6 |
Synonyms | GTPL9714 BI6901 BI 6901 4-(2-cyano-1H-pyrrol-1-yl)-S-(1H-indol-4-yl)-1-(4-methylpiperidin-1-yl)-1-oxobutane-2-sulfonamido BI-6901 |
Inchi Key | BRJXJOWXAFLRTE-OAQYLSRUSA-N |
Inchi ID | InChI=1S/C23H27N5O3S/c1-17-8-13-28(14-9-17)23(29)21(10-15-27-12-3-4-18(27)16-24)26-32(30,31)22-6-2-5-20-19(22)7-11-25-20/h2-7,11-12,17,21,25-26H,8-10,13-15H2,1H3/t21-/m1/s1 |
PubChem CID | 131801164 |
ChEMBL | N/A |
IUPHAR | 9714 |
BindingDB | N/A |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
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IC50 | 1.0 nM | PMID27692854 | IUPHAR |
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