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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Chemokine-like receptor 1
Species	Homo sapiens (Human)
Gene	CMKLR1
Synonym	tazarotene induced gene 2 receptor RVER1 resolvin E1 receptor Gpcr27 G-protein coupled receptor DEZ G-protein coupled receptor ChemR23 CMKLR1 chemokine receptor-like 1 Chemerin1 chemerin receptor 1 TIG2 receptor [ Show all ]
Disease	N/A
Length	373
Amino acid sequence	MRMEDEDYNTSISYGDEYPDYLDSIVVLEDLSPLEARVTRIFLVVVYSIVCFLGILGNGLVIIIATFKMKKTVNMVWFLNLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNFLLIHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTANLHGKISCFNNFSLSTPGSSSWPTHSQMDPVGYSRHMVVTVTRFLCGFLVPVLIITACYLTIVCKLQRNRLAKTKKPFKIIVTIIITFFLCWCPYHTLNLLELHHTAMPGSVFSLGLPLATALAIANSCMNPILYVFMGQDFKKFKVALFSRLVNALSEDTGHSSYPSHRSFTKMSSMNERTSMNERETGML
UniProt	Q99788
Protein Data Bank	N/A
GPCR-HGmod model	Q99788
3D structure model	This predicted structure model is from GPCR-EXP Q99788.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3540
IUPHAR	79
DrugBank	N/A

Ligand

Name	18S-Resolvin E1
Molecular formula	C20H30O5
IUPAC name	(5S,6Z,8E,10E,12R,14Z,16E,18S)-5,12,18-trihydroxyicosa-6,8,10,14,16-pentaenoic acid
Molecular weight	350.455
Hydrogen bond acceptor	5
Hydrogen bond donor	4
XlogP	2.4
Synonyms	SCHEMBL15529308 [3H]RvE1 (5S,12R,18S)-trihydroxy-(6Z,8E,10E,14Z,16E)-icosapentaenoic acid D02GFM GTPL5106 [(3)H]-labeled RvE1 (18S)-resolvin E1 5S,12R,18S-trihydroxy-6Z,8E,10E,14Z,16E-eicosapentaenoic acid (5S,6Z,8E,10E,12R,14Z,16E,18S)-5,12,18-trihydroxyicosa-6,8,10,14,16-pentaenoic acid FA(20:5(OH3)) LMFA03140009 18S-RvE1 [3H]resolvin E1 (5S,12R,18S)-trihydroxy-(6Z,8E,10E,14Z,16E)-eicosapentaenoic acid CHEBI:137038 (5S,6Z,8E,10E,12R,14Z,16E,18S)-5,12,18-trihydroxyicosapentaenoic acid GTPL2901 [ Show all ]
Inchi Key	AOPOCGPBAIARAV-JJVMZPRHSA-N
Inchi ID	InChI=1S/C20H30O5/c1-2-17(21)11-8-5-9-14-18(22)12-6-3-4-7-13-19(23)15-10-16-20(24)25/h3-9,11-13,17-19,21-23H,2,10,14-16H2,1H3,(H,24,25)/b4-3+,9-5-,11-8+,12-6+,13-7-/t17-,18-,19+/m0/s1
PubChem CID	52921890
ChEMBL	N/A
IUPHAR	2901
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Kd	11.0 nM	PMID15753205, PMID17339491	IUPHAR

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