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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Glucagon receptor
Species	Homo sapiens (Human)
Gene	GCGR
Synonym	GL-R GGR GR glucagon receptor
Disease	Diabetes Type 2 diabetes Non-insulin dependent diabetes Obesity; Diabetes Type 1 diabetes Hypoglycemia [ Show all ]
Length	477
Amino acid sequence	MPPCQPQRPLLLLLLLLACQPQVPSAQVMDFLFEKWKLYGDQCHHNLSLLPPPTELVCNRTFDKYSCWPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPDGQWVRGPRGQPWRDASQCQMDGEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTRNAIHANLFASFVLKASSVLVIDGLLRTRYSQKIGDDLSVSTWLSDGAVAGCRVAAVFMQYGIVANYCWLLVEGLYLHNLLGLATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQCWTSNDNMGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTDYKFRLAKSTLTLIPLLGVHEVVFAFVTDEHAQGTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRLGKVLWEERNTSNHRASSSPGHGPPSKELQFGRGGGSQDSSAETPLAGGLPRLAESPF
UniProt	P47871
Protein Data Bank	5yqz, 5xez, 5ee7, 5xf1
GPCR-HGmod model	P47871
3D structure model	This structure is from PDB ID 5yqz.
BioLiP	BL0379634,BL0379635, BL0402227, BL0379636,BL0379637, BL0343437
Therapeutic Target Database	T60182, T87875
ChEMBL	CHEMBL1985
IUPHAR	251
DrugBank	N/A

Ligand

Name	CHEMBL3944843
Molecular formula	C34H33ClFN3O3S
IUPAC name	3-[[4-[(2R)-1-(4-chlorophenyl)-1-[5-fluoro-7-(2-methylpyrazol-3-yl)-1-benzothiophen-3-yl]hexan-2-yl]benzoyl]amino]propanoic acid
Molecular weight	618.164
Hydrogen bond acceptor	6
Hydrogen bond donor	2
XlogP	8.0
Synonyms	N/A
Inchi Key	AQUZMSQNDJPTEI-RNWYOQHESA-N
Inchi ID	InChI=1S/C34H33ClFN3O3S/c1-3-4-5-26(21-6-8-23(9-7-21)34(42)37-16-15-31(40)41)32(22-10-12-24(35)13-11-22)29-20-43-33-27(29)18-25(36)19-28(33)30-14-17-38-39(30)2/h6-14,17-20,26,32H,3-5,15-16H2,1-2H3,(H,37,42)(H,40,41)/t26-,32?/m0/s1
PubChem CID	134145418
ChEMBL	CHEMBL3944843
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
IC50	4.7 nM	None	ChEMBL

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