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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	D(2) dopamine receptor
Species	Rattus norvegicus (Rat)
Gene	Drd2
Synonym	D2 receptor D2(415) and D₂₍₄₄₄₎ D2A and D_2B D2R Dopamine D2 receptor dopamine receptor 2 [ Show all ]
Disease	N/A for non-human GPCRs
Length	444
Amino acid sequence	MDPLNLSWYDDDLERQNWSRPFNGSEGKADRPHYNYYAMLLTLLIFIIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNTDQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKRRKRVNTKRSSRAFRANLKTPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFMKILHC
UniProt	P61169
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL339
IUPHAR	215
DrugBank	N/A

Ligand

Name	CHEMBL3883429
Molecular formula	C22H23Cl2N5O2
IUPAC name	2-(3,4-dichlorophenyl)-6-[3-(4-pyridin-2-ylpiperazin-1-yl)propoxy]pyridazin-3-one
Molecular weight	460.359
Hydrogen bond acceptor	6
Hydrogen bond donor	0
XlogP	3.9
Synonyms	BDBM50208443
Inchi Key	AFXWVOVMMKFRCZ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C22H23Cl2N5O2/c23-18-6-5-17(16-19(18)24)29-22(30)8-7-21(26-29)31-15-3-10-27-11-13-28(14-12-27)20-4-1-2-9-25-20/h1-2,4-9,16H,3,10-15H2
PubChem CID	134131272
ChEMBL	CHEMBL3883429
IUPHAR	N/A
BindingDB	50208443
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	<10000.0 nM	PMID27639363	BindingDB,ChEMBL

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