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GPCR

Name	Alpha-1D adrenergic receptor
Species	Mus musculus (Mouse)
Gene	Adra1d
Synonym	alpha1D-AR alpha1D-adrenoceptor alpha1a/d-adrenoceptor alpha1A/D alpha1A-adrenoceptor Alpha-1D adrenoreceptor Alpha-1D adrenoceptor Adra-1 Alpha-1A adrenergic receptor alpha 1D-adrenoreceptor alpha 1D-adrenoceptor adrenergic receptor delta1 Adrd1 ADRA1R ADRA1A ADRA1 Gpcr8 [ Show all ]
Disease	N/A for non-human GPCRs
Length	562
Amino acid sequence	MTFRDILSVTFEGPRASSSTGGSGAGGGAGTVGPEGPAVGGVPGATGGSAVVGTGSGEDNQSSTAEAGAAASGEVNGSAAVGGLVVSAQGVGVGVFLAAFILTAVAGNLLVILSVACNRHLQTVTNYFIVNLAVADLLLSAAVLPFSATMEVLGFWPFGRTFCDVWAAVDVLCCTASILSLCTISVDRYVGVRHSLKYPAIMTERKAAAILALLWAVALVVSVGPLLGWKEPVPPDERFCGITEEVGYAIFSSVCSFYLPMAVIVVMYCRVYVVARSTTRSLEAGIKREPGKASEVVLRIHCRGAATSAKGNPGTQSSKGHTLRSSLSVRLLKFSREKKAAKTLAIVVGVFVLCWFPFFFVLPLGSLFPQLKPSEGVFKVIFWLGYFNSCVNPLIYPCSSREFKRAFLRLLRCQCRRRRRRLWPSLRPPLASLDRRPALRLCPQPAHRTPRGSPSPHCTPRPGLRRHAGGAGFGLRPSKASLRLREWRLLGPLQRPTTQLRAKVSSLSHKFRSGGARRAETACALRSEVEAVSLNVPQDGAEAVICQAYEPGDLSNLRETDI
UniProt	P97714
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2130
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL3946540
Molecular formula	C21H25ClN2O2
IUPAC name	(2S)-2-[(3-chlorophenoxy)methyl]-4-[2-(2,3-dihydroindol-1-yl)ethyl]morpholine
Molecular weight	372.893
Hydrogen bond acceptor	4
Hydrogen bond donor	0
XlogP	4.1
Synonyms	US9079895, 23s BDBM186935 QAJBOIGVHPCSNX-FQEVSTJZSA-N (S)-2-((3-chlorophenoxy)methyl)-4-(2-(indolin-1-yl)ethyl)morpholine SCHEMBL14060270
Inchi Key	QAJBOIGVHPCSNX-FQEVSTJZSA-N
Inchi ID	InChI=1S/C21H25ClN2O2/c22-18-5-3-6-19(14-18)26-16-20-15-23(12-13-25-20)10-11-24-9-8-17-4-1-2-7-21(17)24/h1-7,14,20H,8-13,15-16H2/t20-/m0/s1
PubChem CID	71061709
ChEMBL	CHEMBL3946540
IUPHAR	N/A
BindingDB	186935
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	4181.0 nM	, None	BindingDB,ChEMBL

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