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GPCR

NameMetabotropic glutamate receptor 2
SpeciesHomo sapiens (Human)
GeneGRM2
SynonymmGluR2
mGlu2 receptor
metabotropic glutamate receptor 2
GPRC1B
glutamate receptor
DiseaseCentral nervous system disease
Anxiety disorder
Bipolar disorder
Major depressive disorder
Mood disorder
[ Show all ]
Length872
Amino acid sequenceMGSLLALLALLLLWGAVAEGPAKKVLTLEGDLVLGGLFPVHQKGGPAEDCGPVNEHRGIQRLEAMLFALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQALDFVRASLSRGADGSRHICPDGSYATHGDAPTAITGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFFQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFELEARARNICVATSEKVGRAMSRAAFEGVVRALLQKPSARVAVLFTRSEDARELLAASQRLNASFTWVASDGWGALESVVAGSEGAAEGAITIELASYPISDFASYFQSLDPWNNSRNPWFREFWEQRFRCSFRQRDCAAHSLRAVPFEQESKIMFVVNAVYAMAHALHNMHRALCPNTTRLCDAMRPVNGRRLYKDFVLNVKFDAPFRPADTHNEVRFDRFGDGIGRYNIFTYLRAGSGRYRYQKVGYWAEGLTLDTSLIPWASPSAGPLPASRCSEPCLQNEVKSVQPGEVCCWLCIPCQPYEYRLDEFTCADCGLGYWPNASLTGCFELPQEYIRWGDAWAVGPVTIACLGALATLFVLGVFVRHNATPVVKASGRELCYILLGGVFLCYCMTFIFIAKPSTAVCTLRRLGLGTAFSVCYSALLTKTNRIARIFGGAREGAQRPRFISPASQVAICLALISGQLLIVVAWLVVEAPGTGKETAPERREVVTLRCNHRDASMLGSLAYNVLLIALCTLYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCVSVSLSGSVVLGCLFAPKLHIILFQPQKNVVSHRAPTSRFGSAAARASSSLGQGSGSQFVPTVCNGREVVDSTTSSL
UniProtQ14416
Protein Data Bank5cnj, 5kzn, 5kzq, 5cni, 4xas, 4xaq
GPCR-HGmod modelN/A
3D structure modelThis structure is from PDB ID 5cnj.
BioLiPBL0365442, BL0324559,BL0324560, BL0324557,BL0324558, BL0306697,BL0306698, BL0306695,BL0306696, BL0365443
Therapeutic Target DatabaseT62820
ChEMBLCHEMBL5137
IUPHAR290
DrugBankN/A

Ligand

NameCHEMBL3956934
Molecular formulaC15H15ClFNO4
IUPAC name(1S,2S,3S,5R,6S)-2-amino-3-[(3-chloro-4-fluorophenyl)methyl]bicyclo[3.1.0]hexane-2,6-dicarboxylic acid
Molecular weight327.736
Hydrogen bond acceptor6
Hydrogen bond donor3
XlogP-0.6
SynonymsBDBM50204253
SCHEMBL8764032
Inchi KeyJYWMNSYAIWOJGC-NAYXSZQVSA-N
Inchi IDInChI=1S/C15H15ClFNO4/c16-9-4-6(1-2-10(9)17)3-7-5-8-11(13(19)20)12(8)15(7,18)14(21)22/h1-2,4,7-8,11-12H,3,5,18H2,(H,19,20)(H,21,22)/t7-,8+,11+,12+,15+/m1/s1
PubChem CID21309795
ChEMBLCHEMBL3956934
IUPHARN/A
BindingDB50204253
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC50312.0 nMPMID27836401BindingDB,ChEMBL

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