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GPCR

NameProteinase-activated receptor 2
SpeciesHomo sapiens (Human)
GeneF2RL1
SynonymProtease-activated receptor-2
PAR2
PAR-2
GPR11
G-protein coupled receptor 11
[ Show all ]
DiseaseN/A
Length397
Amino acid sequenceMRSPSAAWLLGAAILLAASLSCSGTIQGTNRSSKGRSLIGKVDGTSHVTGKGVTVETVFSVDEFSASVLTGKLTTVFLPIVYTIVFVVGLPSNGMALWVFLFRTKKKHPAVIYMANLALADLLSVIWFPLKIAYHIHGNNWIYGEALCNVLIGFFYGNMYCSILFMTCLSVQRYWVIVNPMGHSRKKANIAIGISLAIWLLILLVTIPLYVVKQTIFIPALNITTCHDVLPEQLLVGDMFNYFLSLAIGVFLFPAFLTASAYVLMIRMLRSSAMDENSEKKRKRAIKLIVTVLAMYLICFTPSNLLLVVHYFLIKSQGQSHVYALYIVALCLSTLNSCIDPFVYYFVSHDFRDHAKNALLCRSVRTVKQMQVSLTSKKHSRKSSSYSSSSTTVKTSY
UniProtP55085
Protein Data Bank5ndz, 5ndd
GPCR-HGmod modelP55085
3D structure modelThis structure is from PDB ID 5ndz.
BioLiPBL0377325, BL0377326
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL5963
IUPHAR348
DrugBankN/A

Ligand

NameCHEMBL237968
Molecular formulaC38H64IN11O8
IUPAC name(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-amino-3-hydroxypropanoyl]amino]-4-methylpentanoyl]amino]-3-methylpentanoyl]amino]acetyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-3-(4-iodophenyl)propanoyl]amino]-3-methylpentanamide
Molecular weight929.903
Hydrogen bond acceptor10
Hydrogen bond donor11
XlogP0.7
SynonymsN/A
Inchi KeyIEAAVOQUQXAYQJ-LCEIJQIJSA-N
Inchi IDInChI=1S/C38H64IN11O8/c1-7-21(5)30(32(41)53)49-36(57)28(17-23-11-13-24(39)14-12-23)48-34(55)26(10-9-15-44-38(42)43)46-29(52)18-45-37(58)31(22(6)8-2)50-35(56)27(16-20(3)4)47-33(54)25(40)19-51/h11-14,20-22,25-28,30-31,51H,7-10,15-19,40H2,1-6H3,(H2,41,53)(H,45,58)(H,46,52)(H,47,54)(H,48,55)(H,49,57)(H,50,56)(H4,42,43,44)/t21-,22-,25-,26-,27-,28-,30-,31-/m0/s1
PubChem CID44433874
ChEMBLCHEMBL237968
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has more than 5 hydrogen bond donor.
This ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
EC50600.0 nMPMID17765542ChEMBL

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