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GPCR

NameMuscarinic acetylcholine receptor M2
SpeciesRattus norvegicus (Rat)
GeneChrm2
Synonymcholinergic receptor
cholinergic receptor, muscarinic 2
AChR M2
Chrm-2
M2 muscarinic acetylcholine receptor
[ Show all ]
DiseaseN/A for non-human GPCRs
Length466
Amino acid sequenceMNNSTNSSNNGLAITSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKEKKEPVANQDPVSPSLVQGRIVKPNNNNMPGGDGGLEHNKIQNGKAPRDGVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSRDDNSKQTCIKIVTKAQKGDVCTPTSTTVELVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
UniProtP10980
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL309
IUPHAR14
DrugBankN/A

Ligand

NameCHEMBL68446
Molecular formulaC36H48N6O3
IUPAC name11-[2-[4-[10-[(2-methoxyphenyl)methylamino]decyl]piperazin-1-yl]acetyl]-5H-pyrido[2,3-b][1,4]benzodiazepin-6-one
Molecular weight612.819
Hydrogen bond acceptor7
Hydrogen bond donor2
XlogP4.7
Synonyms5,11-Dihydro-11-[[4-[10-(2-methoxybenzylamino)decyl]-1-piperazinyl]acetyl]-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one
11-(2-{4-[10-(2-Methoxy-benzylamino)-decyl]-piperazin-1-yl}-acetyl)-5,11-dihydro-benzo[e]pyrido[3,2-b][1,4]diazepin-6-one
BDBM50012336
Inchi KeyCYSAQAWEGRPUEE-UHFFFAOYSA-N
Inchi IDInChI=1S/C36H48N6O3/c1-45-33-19-11-8-15-29(33)27-37-20-12-6-4-2-3-5-7-13-22-40-23-25-41(26-24-40)28-34(43)42-32-18-10-9-16-30(32)36(44)39-31-17-14-21-38-35(31)42/h8-11,14-19,21,37H,2-7,12-13,20,22-28H2,1H3,(H,39,44)
PubChem CID15050961
ChEMBLCHEMBL68446
IUPHARN/A
BindingDB50012336
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
Ki22.0 nMPMID2066986BindingDB,ChEMBL

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