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Name | D(3) dopamine receptor |
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Species | Homo sapiens (Human) |
Gene | DRD3 |
Synonym | dopaminergic receptor D3 D3R D3 receptor dopamine D3 receptor |
Disease | Unspecified Emesis; Gastric motility disorder Female sexual dysfunction Male sexual disorders Psychotic disorders [ Show all ] |
Length | 400 |
Amino acid sequence | MASLSQLSSHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC |
UniProt | P35462 |
Protein Data Bank | 3pbl |
GPCR-HGmod model | P35462 |
3D structure model | This structure is from PDB ID 3pbl. |
BioLiP | BL0191566, BL0191567 |
Therapeutic Target Database | T02551 |
ChEMBL | CHEMBL234 |
IUPHAR | 216 |
DrugBank | BE0000581 |
Name | CHEMBL596179 |
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Molecular formula | C18H21NO |
IUPAC name | 10-methyl-10-azatricyclo[12.4.0.03,8]octadeca-1(14),3,5,7,15,17-hexaen-16-ol |
Molecular weight | 267.372 |
Hydrogen bond acceptor | 2 |
Hydrogen bond donor | 1 |
XlogP | 3.7 |
Synonyms | BDBM50304403 6-Methyl-5,6,7,8,9,14-hexahydrodibenzo[c,f]azecin-11-ol |
Inchi Key | CYPJQZCDRFFIJS-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C18H21NO/c1-19-10-4-7-15-12-18(20)9-8-16(15)11-14-5-2-3-6-17(14)13-19/h2-3,5-6,8-9,12,20H,4,7,10-11,13H2,1H3 |
PubChem CID | 46227325 |
ChEMBL | CHEMBL596179 |
IUPHAR | N/A |
BindingDB | 50304403 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Ki | <10000.0 nM | PMID19744859 | BindingDB,ChEMBL |
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