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Name | Chemokine-like receptor 1 |
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Species | Homo sapiens (Human) |
Gene | CMKLR1 |
Synonym | tazarotene induced gene 2 receptor RVER1 resolvin E1 receptor Gpcr27 G-protein coupled receptor DEZ [ Show all ] |
Disease | N/A |
Length | 373 |
Amino acid sequence | MRMEDEDYNTSISYGDEYPDYLDSIVVLEDLSPLEARVTRIFLVVVYSIVCFLGILGNGLVIIIATFKMKKTVNMVWFLNLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNFLLIHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTANLHGKISCFNNFSLSTPGSSSWPTHSQMDPVGYSRHMVVTVTRFLCGFLVPVLIITACYLTIVCKLQRNRLAKTKKPFKIIVTIIITFFLCWCPYHTLNLLELHHTAMPGSVFSLGLPLATALAIANSCMNPILYVFMGQDFKKFKVALFSRLVNALSEDTGHSSYPSHRSFTKMSSMNERTSMNERETGML |
UniProt | Q99788 |
Protein Data Bank | N/A |
GPCR-HGmod model | Q99788 |
3D structure model | This predicted structure model is from GPCR-EXP Q99788. |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL3540 |
IUPHAR | 79 |
DrugBank | N/A |
Name | CHEMBL3920550 |
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Molecular formula | C22H19ClF6N2O2 |
IUPAC name | N-[3,5-bis(trifluoromethyl)phenyl]-1-(2-chlorophenyl)-5-oxo-3-propan-2-ylpyrrolidine-3-carboxamide |
Molecular weight | 492.846 |
Hydrogen bond acceptor | 8 |
Hydrogen bond donor | 1 |
XlogP | 5.4 |
Synonyms | SCHEMBL12728550 |
Inchi Key | FVXGJJBXXFCQIA-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C22H19ClF6N2O2/c1-12(2)20(10-18(32)31(11-20)17-6-4-3-5-16(17)23)19(33)30-15-8-13(21(24,25)26)7-14(9-15)22(27,28)29/h3-9,12H,10-11H2,1-2H3,(H,30,33) |
PubChem CID | 88954744 |
ChEMBL | CHEMBL3920550 |
IUPHAR | N/A |
BindingDB | N/A |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand has a partition coefficient log P greater than 5. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | >30.0 nM | None | ChEMBL |
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