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Name | Chemokine-like receptor 1 |
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Species | Homo sapiens (Human) |
Gene | CMKLR1 |
Synonym | tazarotene induced gene 2 receptor RVER1 resolvin E1 receptor Gpcr27 G-protein coupled receptor DEZ [ Show all ] |
Disease | N/A |
Length | 373 |
Amino acid sequence | MRMEDEDYNTSISYGDEYPDYLDSIVVLEDLSPLEARVTRIFLVVVYSIVCFLGILGNGLVIIIATFKMKKTVNMVWFLNLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNFLLIHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTANLHGKISCFNNFSLSTPGSSSWPTHSQMDPVGYSRHMVVTVTRFLCGFLVPVLIITACYLTIVCKLQRNRLAKTKKPFKIIVTIIITFFLCWCPYHTLNLLELHHTAMPGSVFSLGLPLATALAIANSCMNPILYVFMGQDFKKFKVALFSRLVNALSEDTGHSSYPSHRSFTKMSSMNERTSMNERETGML |
UniProt | Q99788 |
Protein Data Bank | N/A |
GPCR-HGmod model | Q99788 |
3D structure model | This predicted structure model is from GPCR-EXP Q99788. |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL3540 |
IUPHAR | 79 |
DrugBank | N/A |
Name | CHEMBL3891997 |
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Molecular formula | C26H31F3N2O3 |
IUPAC name | (3S,4S)-1-(2,6-dimethylphenyl)-3-ethyl-4-methyl-5-oxo-N-[3-propan-2-yloxy-5-(trifluoromethyl)phenyl]pyrrolidine-3-carboxamide |
Molecular weight | 476.54 |
Hydrogen bond acceptor | 6 |
Hydrogen bond donor | 1 |
XlogP | 5.5 |
Synonyms | SCHEMBL12706899 |
Inchi Key | BHJROALXPGZCRF-IQGLISFBSA-N |
Inchi ID | InChI=1S/C26H31F3N2O3/c1-7-25(14-31(23(32)18(25)6)22-16(4)9-8-10-17(22)5)24(33)30-20-11-19(26(27,28)29)12-21(13-20)34-15(2)3/h8-13,15,18H,7,14H2,1-6H3,(H,30,33)/t18-,25-/m1/s1 |
PubChem CID | 51033797 |
ChEMBL | CHEMBL3891997 |
IUPHAR | N/A |
BindingDB | N/A |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand has a partition coefficient log P greater than 5. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | 30.0 nM | None | ChEMBL |
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