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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	D(4) dopamine receptor
Species	Mus musculus (Mouse)
Gene	Drd4
Synonym	d(2C) dopamine receptor D4 receptor D4R Dopamine D4 receptor dopamine receptor 4
Disease	N/A for non-human GPCRs
Length	387
Amino acid sequence	MGNSSATEDGGLLAGRGPESLGTGAGLGGAGAAALVGGVLLIGLVLAGNSLVCVSVASERTLQTPTNYFIVSLAAADLLLAVLVLPLFVYSEVQGGVWLLSPRLCDTLMAMDVMLCTASIFNLCAISVDRFVAVTVPLRYNQQGQCQLLLIAATWLLSAAVASPVVCGLNDVPGRDPAVCCLENRDYVVYSSVCSFFLPCPLMLLLYWATFRGLRRWEAARHTKLHSRAPRRPSGPGPPVSDPTQGPFFPDCPPPLPSLRTSPSDSSRPESELSQRPCSPGCLLADAALPQPPEPSSRRRRGAKITGRERKAMRVLPVVVGAFLVCWTPFFVVHITRALCPACFVSPRLVSAVTWLGYVNSALNPIIYTIFNAEFRSVFRKTLRLRC
UniProt	P51436
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2574
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL3915107
Molecular formula	C21H23ClN2O3
IUPAC name	2-[(2S)-2-[(3-chlorophenoxy)methyl]morpholin-4-yl]-1-(2,3-dihydroindol-1-yl)ethanone
Molecular weight	386.876
Hydrogen bond acceptor	4
Hydrogen bond donor	0
XlogP	3.4
Synonyms	APCQYPHUPXTFSO-IBGZPJMESA-N (S)-2-(2-((3-Chlorophenoxy)methyl)morpholino)-1-(indolin-1-yl)ethanone BDBM186934 SCHEMBL14060286 US9079895, 22s
Inchi Key	APCQYPHUPXTFSO-IBGZPJMESA-N
Inchi ID	InChI=1S/C21H23ClN2O3/c22-17-5-3-6-18(12-17)27-15-19-13-23(10-11-26-19)14-21(25)24-9-8-16-4-1-2-7-20(16)24/h1-7,12,19H,8-11,13-15H2/t19-/m0/s1
PubChem CID	71061724
ChEMBL	CHEMBL3915107
IUPHAR	N/A
BindingDB	186934
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	536.0 nM	None	ChEMBL
Ki	2858.0 nM	, None	BindingDB,ChEMBL

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