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GPCR

NameMas-related G-protein coupled receptor member X1
SpeciesRattus norvegicus (Rat)
GeneMrgprx1
SynonymSensory neuron-specific G-protein coupled receptor 1
DiseaseN/A for non-human GPCRs
Length323
Amino acid sequenceMDPTISSLSTESTTLNKTGHPSCRPILTLSFLVPIITLLGLAGNTIVLWLLGFRMRRKAISVYVLNLSLADSFFLCCHFIDSLMRIMNFYGIYAHKLSKEILGNAAIIPYISGLSILSAISTERCLSVLWPIWYHCHRPRNMSAIICVLIWVLSFLMGILDWFFSGFLGETHHHLWKNVDFIVTAFLIFLFMLLFGSSLALLVRILCGSRRKPLSRLYVTISLTVMVYLICGLPLGLYLFLLYWFGIHLHYPFCHIYQVTVLLSCVNSSANPIIYFLVGSFRHRKKHRSLKMVLKRALEETPEEDEYTDSHVQKPTEISERRC
UniProtQ8R4G1
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3341575
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL3728009
Molecular formulaC28H31N3OS
IUPAC name1-[(3R)-2-benzhydryl-1-azabicyclo[2.2.2]octan-3-yl]-3-(2-methoxyphenyl)thiourea
Molecular weight457.636
Hydrogen bond acceptor3
Hydrogen bond donor2
XlogP5.6
SynonymsN/A
Inchi KeyPVIGSSNGUGUCED-AVJYQCBHSA-N
Inchi IDInChI=1S/C28H31N3OS/c1-32-24-15-9-8-14-23(24)29-28(33)30-26-22-16-18-31(19-17-22)27(26)25(20-10-4-2-5-11-20)21-12-6-3-7-13-21/h2-15,22,25-27H,16-19H2,1H3,(H2,29,30,33)/t26-,27?/m1/s1
PubChem CID11691090
ChEMBLCHEMBL3728009
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
IC509800.0 nMNoneChEMBL
IC5013500.0 nMNoneChEMBL

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