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GPCR

NameThyrotropin-releasing hormone receptor
SpeciesMus musculus (Mouse)
GeneTrhr
SynonymThyroliberin receptor
TRH receptor
TRH-R
TRH-R1
TRH1 receptor
DiseaseN/A for non-human GPCRs
Length393
Amino acid sequenceMENDTVSEMNQTELQPQAAVALEYQVVTILLVVIICGLGIVGNIMVVLVVMRTKHMRTPTNCYLVSLAVADLMVLVAAGLPNITDSIYGSWVYGYVGCLCITYLQYLGINASSCSITAFTIERYIAICHPIKAQFLCTFSRAKKIIIFVWAFTSIYCMLWFFLLDLNISTYKNAVVVSCGYKISRNYYSPIYLMDFGVFYVVPMILATVLYGFIARILFLNPIPSDPKENSKMWKNDSIHQNKNLNLNATNRCFNSTVSSRKQVTKMLAVVVILFALLWMPYRTLVVVNSFLSSPFQENWFLLFCRICIYLNSAINPVIYNLMSQKFRAAFRKLCNCKQKPTEKAANYSVALNYSVIKESDRFSTELEDITVTDTYVSTTKVSFDDTCLASEN
UniProtP21761
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL2467
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL3780633
Molecular formulaC17H22I2N6O4
IUPAC name(2S)-N-[(2S)-1-[(2S)-2-carbamoylpyrrolidin-1-yl]-3-(2,5-diiodo-1-methylimidazol-4-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide
Molecular weight628.21
Hydrogen bond acceptor5
Hydrogen bond donor3
XlogP-1.1
SynonymsBDBM50158398
Inchi KeyMNYJRTHLXBWSPD-LSJOCFKGSA-N
Inchi IDInChI=1S/C17H22I2N6O4/c1-24-13(18)9(23-17(24)19)7-10(22-15(28)8-4-5-12(26)21-8)16(29)25-6-2-3-11(25)14(20)27/h8,10-11H,2-7H2,1H3,(H2,20,27)(H,21,26)(H,22,28)/t8-,10-,11-/m0/s1
PubChem CID127032878
ChEMBLCHEMBL3780633
IUPHARN/A
BindingDB50158398
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
Activity164.66 cpmPMID26854379ChEMBL
Activity539.08 cpmPMID26854379ChEMBL
Activity715.17 cpmPMID26854379ChEMBL
Activity840.01 cpmPMID26854379ChEMBL
Activity1025.05 cpmPMID26854379ChEMBL
Activity1444.14 cpmPMID26854379ChEMBL
Activity1553.42 cpmPMID26854379ChEMBL
Activity1667.45 cpmPMID26854379ChEMBL
Activity1933.6 cpmPMID26854379ChEMBL
Activity2244.16 cpmPMID26854379ChEMBL
Activity2536.0 cpmPMID26854379ChEMBL
EC50272.0 nMPMID26854379BindingDB,ChEMBL
EC5036350.0 nMPMID26854379BindingDB,ChEMBL
IC5048030.0 nMPMID26854379BindingDB,ChEMBL

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