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GPCR

NameC-C chemokine receptor type 10
SpeciesHomo sapiens (Human)
GeneCCR10
SynonymCCR-10
CCR10
CC-CKR-10
G-protein coupled receptor 2
GPR-2
[ Show all ]
DiseaseInflammatory disease
Length362
Amino acid sequenceMGTEATEQVSWGHYSGDEEDAYSAEPLPELCYKADVQAFSRAFQPSVSLTVAALGLAGNGLVLATHLAARRAARSPTSAHLLQLALADLLLALTLPFAAAGALQGWSLGSATCRTISGLYSASFHAGFLFLACISADRYVAIARALPAGPRPSTPGRAHLVSVIVWLLSLLLALPALLFSQDGQREGQRRCRLIFPEGLTQTVKGASAVAQVALGFALPLGVMVACYALLGRTLLAARGPERRRALRVVVALVAAFVVLQLPYSLALLLDTADLLAARERSCPASKRKDVALLVTSGLALARCGLNPVLYAFLGLRFRQDLRRLLRGGSCPSGPQPRRGCPRRPRLSSCSAPTETHSLSWDN
UniProtP46092
Protein Data BankN/A
GPCR-HGmod modelP46092
3D structure modelThis predicted structure model is from GPCR-EXP P46092.
BioLiPN/A
Therapeutic Target DatabaseT71054
ChEMBLCHEMBL2321628
IUPHAR67
DrugBankN/A

Ligand

NameCHEMBL3732652
Molecular formulaC28H30FN7O3S2
IUPAC name1-ethyl-3-[7-(4-fluoro-2-methylanilino)-6-(4-phenylpiperidine-1-carbonyl)pyrazolo[1,5-a]pyrimidin-3-yl]sulfonylthiourea
Molecular weight595.712
Hydrogen bond acceptor8
Hydrogen bond donor3
XlogP4.5
SynonymsSCHEMBL15914915
Inchi KeyHZGUAAQYQHWQGR-UHFFFAOYSA-N
Inchi IDInChI=1S/C28H30FN7O3S2/c1-3-30-28(40)34-41(38,39)24-17-32-36-25(33-23-10-9-21(29)15-18(23)2)22(16-31-26(24)36)27(37)35-13-11-20(12-14-35)19-7-5-4-6-8-19/h4-10,15-17,20,33H,3,11-14H2,1-2H3,(H2,30,34,40)
PubChem CID90312482
ChEMBLCHEMBL3732652
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
Inhibition81.8 %NoneChEMBL

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