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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	N-formyl peptide receptor 2
Species	Homo sapiens (Human)
Gene	FPR2
Synonym	FPRH1 FPRH2 FPRL1 HM63 Lipoxin A4 receptor LXA4 receptor LXA4R FPR2A FPR2/ALX Fpr-rs2 ALX ALX/FPR2 ALXR FMLP-R-I FMLP-related receptor I FMLPX formyl peptide receptor 2 formyl peptide receptor, related sequence 2 Formyl peptide receptor-like 1 RFP [ Show all ]
Disease	N/A
Length	351
Amino acid sequence	METNFSTPLNEYEEVSYESAGYTVLRILPLVVLGVTFVLGVLGNGLVIWVAGFRMTRTVTTICYLNLALADFSFTATLPFLIVSMAMGEKWPFGWFLCKLIHIVVDINLFGSVFLIGFIALDRCICVLHPVWAQNHRTVSLAMKVIVGPWILALVLTLPVFLFLTTVTIPNGDTYCTFNFASWGGTPEERLKVAITMLTARGIIRFVIGFSLPMSIVAICYGLIAAKIHKKGMIKSSRPLRVLTAVVASFFICWFPFQLVALLGTVWLKEMLFYGKYKIIDILVNPTSSLAFFNSCLNPMLYVFVGQDFRERLIHSLPTSLERALSEDSAPTNDTAANSASPPAETELQAM
UniProt	P25090
Protein Data Bank	N/A
GPCR-HGmod model	P25090
3D structure model	This predicted structure model is from GPCR-EXP P25090.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4227
IUPHAR	223
DrugBank	N/A

Ligand

Name	SCHEMBL2683244
Molecular formula	C21H25BrN2O2
IUPAC name	(1S,2R,3R,4R)-N-(4-bromophenyl)-3-[(butanoylamino)methyl]spiro[bicyclo[2.2.1]hept-5-ene-7,1'-cyclopropane]-2-carboxamide
Molecular weight	417.347
Hydrogen bond acceptor	2
Hydrogen bond donor	2
XlogP	3.6
Synonyms	CHEMBL3728603
Inchi Key	BTXGCGMTPONHII-VXNCWWDNSA-N
Inchi ID	InChI=1S/C21H25BrN2O2/c1-2-3-18(25)23-12-15-16-8-9-17(21(16)10-11-21)19(15)20(26)24-14-6-4-13(22)5-7-14/h4-9,15-17,19H,2-3,10-12H2,1H3,(H,23,25)(H,24,26)/t15-,16-,17+,19+/m1/s1
PubChem CID	67495885
ChEMBL	CHEMBL3728603
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	505.0 nM	None	ChEMBL

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