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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	G-protein coupled receptor 35
Species	Homo sapiens (Human)
Gene	GPR35
Synonym	G-protein coupled receptor 3 GPR35 KYNA receptor Kynurenic acid receptor
Disease	N/A
Length	309
Amino acid sequence	MNGTYNTCGSSDLTWPPAIKLGFYAYLGVLLVLGLLLNSLALWVFCCRMQQWTETRIYMTNLAVADLCLLCTLPFVLHSLRDTSDTPLCQLSQGIYLTNRYMSISLVTAIAVDRYVAVRHPLRARGLRSPRQAAAVCAVLWVLVIGSLVARWLLGIQEGGFCFRSTRHNFNSMAFPLLGFYLPLAVVVFCSLKVVTALAQRPPTDVGQAEATRKAARMVWANLLVFVVCFLPLHVGLTVRLAVGWNACALLETIRRALYITSKLSDANCCLDAICYYYMAKEFQEASALAVAPSAKAHKSQDSLCVTLA
UniProt	Q9HC97
Protein Data Bank	N/A
GPCR-HGmod model	Q9HC97
3D structure model	This predicted structure model is from GPCR-EXP Q9HC97.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL1293267
IUPHAR	102
DrugBank	BE0005562

Ligand

Name	CHEMBL2425822
Molecular formula	C19H15NO6
IUPAC name	8-[(4-methoxybenzoyl)amino]-6-methyl-4-oxochromene-2-carboxylic acid
Molecular weight	353.33
Hydrogen bond acceptor	6
Hydrogen bond donor	2
XlogP	2.5
Synonyms	BDBM50440039 4-Oxo-6-methyl-8-(p-methoxybenzoylamino)-2-chromene-2-carboxylic acid
Inchi Key	CVGSJQCEOMANDN-UHFFFAOYSA-N
Inchi ID	InChI=1S/C19H15NO6/c1-10-7-13-15(21)9-16(19(23)24)26-17(13)14(8-10)20-18(22)11-3-5-12(25-2)6-4-11/h3-9H,1-2H3,(H,20,22)(H,23,24)
PubChem CID	73294509
ChEMBL	CHEMBL2425822
IUPHAR	N/A
BindingDB	50440039
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	37.7 nM	PMID23888932	ChEMBL
EC50	38.0 nM	PMID23888932	BindingDB
Emax	118.0 %	PMID23888932	ChEMBL
Ki	42.8 nM	PMID23888932	ChEMBL
Ki	43.0 nM	PMID23888932	BindingDB

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