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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Sphingosine 1-phosphate receptor 2
Species	Homo sapiens (Human)
Gene	S1PR2
Synonym	Endothelial differentiation G-protein coupled receptor 5 Sphingosine 1-phosphate receptor Edg-5 S1P2 receptor S1P2 S1P receptor Edg-5 S1P receptor 2 edg5 endothelial differentiation G protein-coupled receptor 5 GPCR18 Gpcr13 G protein-coupled receptor 13 [ Show all ]
Disease	Hypertension
Length	353
Amino acid sequence	MGSLYSEYLNPNKVQEHYNYTKETLETQETTSRQVASAFIVILCCAIVVENLLVLIAVARNSKFHSAMYLFLGNLAASDLLAGVAFVANTLLSGSVTLRLTPVQWFAREGSAFITLSASVFSLLAIAIERHVAIAKVKLYGSDKSCRMLLLIGASWLISLVLGGLPILGWNCLGHLEACSTVLPLYAKHYVLCVVTIFSIILLAIVALYVRIYCVVRSSHADMAAPQTLALLKTVTIVLGVFIVCWLPAFSILLLDYACPVHSCPILYKAHYFFAVSTLNSLLNPVIYTWRSRDLRREVLRPLQCWRPGVGVQGRRRGGTPGHHLLPLRSSSSLERGMHMPTSPTFLEGNTVV
UniProt	O95136
Protein Data Bank	N/A
GPCR-HGmod model	O95136
3D structure model	This predicted structure model is from GPCR-EXP O95136.
BioLiP	N/A
Therapeutic Target Database	T47888
ChEMBL	CHEMBL2955
IUPHAR	276
DrugBank	N/A

Ligand

Name	CYM50199
Molecular formula	C14H12BrCl2NO2
IUPAC name	2-bromo-3-[2-(2,4-dichlorophenoxy)ethoxy]-6-methylpyridine
Molecular weight	377.059
Hydrogen bond acceptor	3
Hydrogen bond donor	0
XlogP	5.2
Synonyms	CHEBI:92299 SR-02000000306-1 2-bromo-3-[2-(2,4-dichlorophenoxy)ethoxy]-6-methyl-pyridine cid_44620895 SMR001828628 2-bromo-3-[2-(2,4-dichlorophenoxy)ethoxy]-6-methylpyridine BDBM75604 SR-02000000306 CHEMBL1722064 3-[2-[2,4-bis(chloranyl)phenoxy]ethoxy]-2-bromanyl-6-methyl-pyridine MLS003115020 [ Show all ]
Inchi Key	AGOUWTBVEAKQIJ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C14H12BrCl2NO2/c1-9-2-4-13(14(15)18-9)20-7-6-19-12-5-3-10(16)8-11(12)17/h2-5,8H,6-7H2,1H3
PubChem CID	44620895
ChEMBL	CHEMBL1722064
IUPHAR	N/A
BindingDB	75604
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
EC50	<50000.0 nM	, PubChem BioAssay data set	BindingDB,ChEMBL

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