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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Corticotropin-releasing factor receptor 2
Species	Homo sapiens (Human)
Gene	CRHR2
Synonym	CRH-R2 CRH-R-2 CRFR2beta CRFR2alpha CRFR2 CRFR-2 CRF2 receptor CRF-R2 CRF-R-2 CRF 2 receptor Corticotropin-releasing hormone receptor 2 [ Show all ]
Disease	Generalized anxiety disorder Anxiety disorder Congestive heart failure Eating disorders stimulate food consumption anxiety
Length	411
Amino acid sequence	MDAALLHSLLEANCSLALAEELLLDGWGPPLDPEGPYSYCNTTLDQIGTCWPRSAAGALVERPCPEYFNGVKYNTTRNAYRECLENGTWASKINYSQCEPILDDKQRKYDLHYRIALVVNYLGHCVSVAALVAAFLLFLALRSIRCLRNVIHWNLITTFILRNVMWFLLQLVDHEVHESNEVWCRCITTIFNYFVVTNFFWMFVEGCYLHTAIVMTYSTERLRKCLFLFIGWCIPFPIIVAWAIGKLYYENEQCWFGKEPGDLVDYIYQGPIILVLLINFVFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDDLSQIMFIYFNSFLQSFQGFFVSVFYCFFNGEVRSAVRKRWHRWQDHHSLRVPMARAMSIPTSPTRISFHSIKQTAAV
UniProt	Q13324
Protein Data Bank	N/A
GPCR-HGmod model	Q13324
3D structure model	This predicted structure model is from GPCR-EXP Q13324.
BioLiP	N/A
Therapeutic Target Database	T11011
ChEMBL	CHEMBL4069
IUPHAR	213
DrugBank	N/A

Ligand

Name	CHEMBL3628733
Molecular formula	C22H30N4O
IUPAC name	8-[butyl(ethyl)amino]-4-(2,4-dimethylphenyl)-6-methyl-1,3-dihydropyrido[2,3-b]pyrazin-2-one
Molecular weight	366.509
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	4.7
Synonyms	BDBM50128777 SCHEMBL3805123
Inchi Key	VQWFJCHKPPMPFF-UHFFFAOYSA-N
Inchi ID	InChI=1S/C22H30N4O/c1-6-8-11-25(7-2)19-13-17(5)23-22-21(19)24-20(27)14-26(22)18-10-9-15(3)12-16(18)4/h9-10,12-13H,6-8,11,14H2,1-5H3,(H,24,27)
PubChem CID	46872036
ChEMBL	CHEMBL3628733
IUPHAR	N/A
BindingDB	50128777
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Inhibition	6.8 %	PMID26456805	ChEMBL

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