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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Alpha-2B adrenergic receptor
Species	Homo sapiens (Human)
Gene	ADRA2B
Synonym	alpha2-C2 alpha2B alpha2B-adrenoceptor Alpha-2BAR alpha-2B adrenoreceptor Alpha-2B adrenoceptor alpha-2B adrenergic receptor Alpha-2 adrenergic receptor subtype C2 adrenergic receptor Adrenergic alpha2B- receptor class III ADRA2RL1 ADRA2L1 Adra-2b [ Show all ]
Disease	Neuropathic pain Alcohol use disorders
Length	450
Amino acid sequence	MDHQDPYSVQATAAIAAAITFLILFTIFGNALVILAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLANELLGYWYFRRTWCEVYLALDVLFCTSSIVHLCAISLDRYWAVSRALEYNSKRTPRRIKCIILTVWLIAAVISLPPLIYKGDQGPQPRGRPQCKLNQEAWYILASSIGSFFAPCLIMILVYLRIYLIAKRSNRRGPRAKGGPGQGESKQPRPDHGGALASAKLPALASVASAREVNGHSKSTGEKEEGETPEDTGTRALPPSWAALPNSGQGQKEGVCGASPEDEAEEEEEEEEEEEECEPQAVPVSPASACSPPLQQPQGSRVLATLRGQVLLGRGVGAIGGQWWRRRAQLTREKRFTFVLAVVIGVFVLCWFPFFFSYSLGAICPKHCKVPHGLFQFFFWIGYCNSSLNPVIYTIFNQDFRRAFRRILCRPWTQTAW
UniProt	P18089
Protein Data Bank	N/A
GPCR-HGmod model	P18089
3D structure model	This predicted structure model is from GPCR-EXP P18089.
BioLiP	N/A
Therapeutic Target Database	T41580
ChEMBL	CHEMBL1942
IUPHAR	26
DrugBank	BE0000572

Ligand

Name	CHEMBL1203618
Molecular formula	C27H32ClNO3
IUPAC name	(2S,3S)-3-(3,3-diphenylpropylamino)-6,7-dimethoxy-1,2,3,4-tetrahydronaphthalen-2-ol;hydrochloride
Molecular weight	454.007
Hydrogen bond acceptor	4
Hydrogen bond donor	3
XlogP	None
Synonyms	BDBM50452419
Inchi Key	CTECFHYOZGEUNI-DKIIUIKKSA-N
Inchi ID	InChI=1S/C27H31NO3.ClH/c1-30-26-17-21-15-24(25(29)16-22(21)18-27(26)31-2)28-14-13-23(19-9-5-3-6-10-19)20-11-7-4-8-12-20;/h3-12,17-18,23-25,28-29H,13-16H2,1-2H3;1H/t24-,25-;/m0./s1
PubChem CID	49861084
ChEMBL	CHEMBL1203618
IUPHAR	N/A
BindingDB	50452419
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	Partition coefficient log P of this ligand is not available.

Experimental Data

Parameter	Value	Reference	Database source
Kd	1000.0 nM	PMID2435902	BindingDB

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