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GPCR

NameProbable G-protein coupled receptor 174
SpeciesHomo sapiens (Human)
GeneGPR174
SynonymFKSG79
GPR174
DiseaseN/A
Length333
Amino acid sequenceMPANYTCTRPDGDNTDFRYFIYAVTYTVILVPGLIGNILALWVFYGYMKETKRAVIFMINLAIADLLQVLSLPLRIFYYLNHDWPFGPGLCMFCFYLKYVNMYASIYFLVCISVRRFWFLMYPFRFHDCKQKYDLYISIAGWLIICLACVLFPLLRTSDDTSGNRTKCFVDLPTRNVNLAQSVVMMTIGELIGFVTPLLIVLYCTWKTVLSLQDKYPMAQDLGEKQKALKMILTCAGVFLICFAPYHFSFPLDFLVKSNEIKSCLARRVILIFHSVALCLASLNSCLDPVIYYFSTNEFRRRLSRQDLHDSIQLHAKSFVSNHTASTMTPELC
UniProtQ9BXC1
Protein Data BankN/A
GPCR-HGmod modelQ9BXC1
3D structure modelThis predicted structure model is from GPCR-EXP Q9BXC1.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3562167
IUPHAR145
DrugBankN/A

Ligand

NameCHEMBL3577169
Molecular formulaC22H36NO10P
IUPAC name(2S)-2-amino-3-[[(2R)-3-[3-(4-heptoxyphenyl)propanoyloxy]-2-hydroxypropoxy]-hydroxyphosphoryl]oxypropanoic acid
Molecular weight505.501
Hydrogen bond acceptor11
Hydrogen bond donor4
XlogP-0.6
SynonymsBDBM50096440
Inchi KeyQGNSHRQSKZGWBU-QUCCMNQESA-N
Inchi IDInChI=1S/C22H36NO10P/c1-2-3-4-5-6-13-30-19-10-7-17(8-11-19)9-12-21(25)31-14-18(24)15-32-34(28,29)33-16-20(23)22(26)27/h7-8,10-11,18,20,24H,2-6,9,12-16,23H2,1H3,(H,26,27)(H,28,29)/t18-,20+/m1/s1
PubChem CID122177515
ChEMBLCHEMBL3577169
IUPHARN/A
BindingDB50096440
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has more than 10 hydrogen bond acceptor.
This ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
EC50489.78 nMPMID25970039ChEMBL
EC50490.0 nMPMID25970039BindingDB,ChEMBL

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