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GLASS

You can:

Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Histamine H3 receptor
Species	Rattus norvegicus (Rat)
Gene	Hrh3
Synonym	GPCR97 H3 receptor H3R HH3R
Disease	N/A for non-human GPCRs
Length	445
Amino acid sequence	MERAPPDGLMNASGTLAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCASSVFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMALVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGGREAGPEPPPDAQPSPPPAPPSCWGCWPKGHGEAMPLHRYGVGEAGPGVEAGEAALGGGSGGGAAASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSITQRFRLSRDKKVAKSLAIIVSIFGLCWAPYTLLMIIRAACHGRCIPDYWYETSFWLLWANSAVNPVLYPLCHYSFRRAFTKLLCPQKLKVQPHGSLEQCWK
UniProt	Q9QYN8
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4124
IUPHAR	264
DrugBank	N/A

Ligand

Name	CHEMBL12494
Molecular formula	C15H19N3O
IUPAC name	N-[2-(1H-imidazol-5-yl)ethyl]-4-phenylbutanamide
Molecular weight	257.337
Hydrogen bond acceptor	2
Hydrogen bond donor	2
XlogP	1.9
Synonyms	PDSP1_000546 STK592424 MLS001216220 BDBM50406098 N-[2-(1H-Imidazol-4-yl)ethyl]-4-phenylbutyramide HMS2868E19 PDSP2_000544 ZINC13591247 AKOS005514328 MolPort-002-659-796 N-[2-(1H-imidazol-5-yl)ethyl]-4-phenylbutanamide 160208-26-4 MCULE-2172098265 SMR000544443 AKOS032398356 MolPort-005-911-500 [ Show all ]
Inchi Key	AGKVFFJHDCPNSM-UHFFFAOYSA-N
Inchi ID	InChI=1S/C15H19N3O/c19-15(17-10-9-14-11-16-12-18-14)8-4-7-13-5-2-1-3-6-13/h1-3,5-6,11-12H,4,7-10H2,(H,16,18)(H,17,19)
PubChem CID	10106513
ChEMBL	CHEMBL12494
IUPHAR	N/A
BindingDB	50406098
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	79.43 nM	PMID1967317	BindingDB,ChEMBL

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