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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Sphingosine 1-phosphate receptor 2
Species	Homo sapiens (Human)
Gene	S1PR2
Synonym	Endothelial differentiation G-protein coupled receptor 5 Sphingosine 1-phosphate receptor Edg-5 S1P2 receptor S1P2 S1P receptor Edg-5 S1P receptor 2 edg5 endothelial differentiation G protein-coupled receptor 5 GPCR18 Gpcr13 G protein-coupled receptor 13 [ Show all ]
Disease	Hypertension
Length	353
Amino acid sequence	MGSLYSEYLNPNKVQEHYNYTKETLETQETTSRQVASAFIVILCCAIVVENLLVLIAVARNSKFHSAMYLFLGNLAASDLLAGVAFVANTLLSGSVTLRLTPVQWFAREGSAFITLSASVFSLLAIAIERHVAIAKVKLYGSDKSCRMLLLIGASWLISLVLGGLPILGWNCLGHLEACSTVLPLYAKHYVLCVVTIFSIILLAIVALYVRIYCVVRSSHADMAAPQTLALLKTVTIVLGVFIVCWLPAFSILLLDYACPVHSCPILYKAHYFFAVSTLNSLLNPVIYTWRSRDLRREVLRPLQCWRPGVGVQGRRRGGTPGHHLLPLRSSSSLERGMHMPTSPTFLEGNTVV
UniProt	O95136
Protein Data Bank	N/A
GPCR-HGmod model	O95136
3D structure model	This predicted structure model is from GPCR-EXP O95136.
BioLiP	N/A
Therapeutic Target Database	T47888
ChEMBL	CHEMBL2955
IUPHAR	276
DrugBank	N/A

Ligand

Name	SR-01000051804-2
Molecular formula	C19H19N3OS
IUPAC name	1-(1-benzyl-2,5-dimethylpyrrol-3-yl)-2-pyrimidin-2-ylsulfanylethanone
Molecular weight	337.441
Hydrogen bond acceptor	4
Hydrogen bond donor	0
XlogP	3.6
Synonyms	HMS1722M09 AKOS000857201 SR-01000051804 1-(1-benzyl-2,5-dimethyl-1H-pyrrol-3-yl)-2-(pyrimidin-2-ylsulfanyl)ethan-1-one CHEMBL1472755 Z18380664 1-[2,5-dimethyl-1-(phenylmethyl)-3-pyrrolyl]-2-(2-pyrimidinylthio)ethanone 745024-13-9 MCULE-8915674172 BDBM41741 SR-01000051804-1 1-(1-benzyl-2,5-dimethyl-pyrrol-3-yl)-2-(2-pyrimidylthio)ethanone cid_2100427 ZINC2637647 1-[2,5-dimethyl-1-(phenylmethyl)pyrrol-3-yl]-2-pyrimidin-2-ylsulfanyl-ethanone AC1M1KO7 MolPort-003-217-119 1-(1-benzyl-2,5-dimethylpyrrol-3-yl)-2-pyrimidin-2-ylsulfanylethanone [ Show all ]
Inchi Key	AGKOKHVKNMPUPG-UHFFFAOYSA-N
Inchi ID	InChI=1S/C19H19N3OS/c1-14-11-17(18(23)13-24-19-20-9-6-10-21-19)15(2)22(14)12-16-7-4-3-5-8-16/h3-11H,12-13H2,1-2H3
PubChem CID	2100427
ChEMBL	CHEMBL1472755
IUPHAR	N/A
BindingDB	41741
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	<30000.0 nM	, PubChem BioAssay data set	BindingDB,ChEMBL
EC50	<44000.0 nM	, PubChem BioAssay data set	BindingDB,ChEMBL

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