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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	G-protein coupled receptor 183
Species	Homo sapiens (Human)
Gene	GPR183
Synonym	EBI2 {ECO:0000303\|PubMed:8383238} lymphocyte-specific G protein-coupled receptor hEBI2 {ECO:0000303\|PubMed:22875855} GPR183 G protein-coupled receptor 183 EBI2 Epstein-Barr virus-induced G-protein coupled receptor 2 {ECO:0000303\|PubMed:8383238} EBV-induced G-protein coupled receptor 2 {ECO:0000303\|PubMed:8383238} EBV-induced G protein-coupled receptor 2 Epstein-Barr virus-induced gene 2 [ Show all ]
Disease	N/A
Length	361
Amino acid sequence	MDIQMANNFTPPSATPQGNDCDLYAHHSTARIVMPLHYSLVFIIGLVGNLLALVVIVQNRKKINSTTLYSTNLVISDILFTTALPTRIAYYAMGFDWRIGDALCRITALVFYINTYAGVNFMTCLSIDRFIAVVHPLRYNKIKRIEHAKGVCIFVWILVFAQTLPLLINPMSKQEAERITCMEYPNFEETKSLPWILLGACFIGYVLPLIIILICYSQICCKLFRTAKQNPLTEKSGVNKKALNTIILIIVVFVLCFTPYHVAIIQHMIKKLRFSNFLECSQRHSFQISLHFTVCLMNFNCCMDPFIYFFACKGYKRKVMRMLKRQVSVSISSAVKSAPEENSREMTETQMMIHSKSSNGK
UniProt	P32249
Protein Data Bank	N/A
GPCR-HGmod model	P32249
3D structure model	This predicted structure model is from GPCR-EXP P32249.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3259470
IUPHAR	81
DrugBank	N/A

Ligand

Name	CHEMBL3561867
Molecular formula	C20H18BrF3N2O3S
IUPAC name	(E)-1-[4-(4-bromophenyl)sulfonylpiperazin-1-yl]-3-[2-(trifluoromethyl)phenyl]prop-2-en-1-one
Molecular weight	503.334
Hydrogen bond acceptor	7
Hydrogen bond donor	0
XlogP	4.0
Synonyms	SBI-0646691.0001 SCHEMBL16598874 SCHEMBL16598877
Inchi Key	PCKLBGBPIIKUCN-BJMVGYQFSA-N
Inchi ID	InChI=1S/C20H18BrF3N2O3S/c21-16-6-8-17(9-7-16)30(28,29)26-13-11-25(12-14-26)19(27)10-5-15-3-1-2-4-18(15)20(22,23)24/h1-10H,11-14H2/b10-5+
PubChem CID	73330408
ChEMBL	CHEMBL3561867
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
IC50	310.0 nM	PubChem BioAssay data set	ChEMBL

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