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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Lysophosphatidic acid receptor 1
Species	Mus musculus (Mouse)
Gene	Lpar1
Synonym	VZG-1 {ECO:0000303\|PubMed:8922387, ECO:0000303\|PubMed:9600933} Rec1.3 {ECO:0000303\|PubMed:9013780} Lysophosphatidic acid receptor Edg-2 {ECO:0000303\|PubMed:9600933} lysophosphatidic acid receptor Edg-2 Lpar1 LPA1 receptor LPA-1 {ECO:0000303\|PubMed:9600933, ECO:0000303\|PubMed:9721207} LPA receptor 1 {ECO:0000305} LPA receptor 1 GPR26 endothelial differentiation gene 2, lysophosphatidic acid G-protein-coupled receptor, 2 EDG2 VZG1 [ Show all ]
Disease	N/A for non-human GPCRs
Length	364
Amino acid sequence	MAAASTSSPVISQPQFTAMNEQQCFYNESIAFFYNRSGKYLATEWNTVSKLVMGLGITVCVFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLIDTSLTASVANLLAIAIERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIDHCSNMAPLYSDSYLVFWAIFNLVTFVVMVVLYAHIFGYVRQRTMRMSRHSSGPRRNRDTMMSLLKTVVIVLGAFIVCWTPGLVLLLLDVCCPQCDVLAYEKFFLLLAEFNSAMNPIIYSYRDKEMSATFRQILCCQRNENPNGPTEGSDRSASSLNHTILAGVHSNDHSVV
UniProt	P61793
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3621025
IUPHAR	272
DrugBank	N/A

Ligand

Name	CHEMBL3621956
Molecular formula	C21H42NO6P
IUPAC name	[(2R)-3-hydroxy-2-[[(Z)-octadec-9-enoyl]amino]propyl] dihydrogen phosphate
Molecular weight	435.542
Hydrogen bond acceptor	6
Hydrogen bond donor	4
XlogP	4.6
Synonyms	N-{(1r)-2-hydroxy-1-[(phosphonooxy)methyl]ethyl}(9z)octadec-9-enamide SCHEMBL13109923
Inchi Key	OTPODXRPJGBQEK-GDCKJWNLSA-N
Inchi ID	InChI=1S/C21H42NO6P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-21(24)22-20(18-23)19-28-29(25,26)27/h9-10,20,23H,2-8,11-19H2,1H3,(H,22,24)(H2,25,26,27)/b10-9-/t20-/m1/s1
PubChem CID	58787991
ChEMBL	CHEMBL3621956
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	7.9 nM	MedChemComm, (2015) 6:1:13	ChEMBL

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