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GLASS

You can:

Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Glucose-dependent insulinotropic receptor
Species	Mus musculus (Mouse)
Gene	Gpr119
Synonym	G protein-coupled receptor 119 G-protein coupled receptor 119 G-protein coupled receptor 2 glucose-dependent insulinotropic receptor GPCR2 GPR119 [ Show all ]
Disease	N/A for non-human GPCRs
Length	335
Amino acid sequence	MESSFSFGVILAVLTILIIAVNALVVVAMLLSIYKNDGVGLCFTLNLAVADTLIGVAISGLVTDQLSSSAQHTQKTLCSLRMAFVTSSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGACIAGLWLVSYLIGFLPLGVSIFQQTTYHGPCSFFAVFHPRFVLTLSCAGFFPAVLLFVFFYCDMLKIASVHSQQIRKMEHAGAMAGAYRPPRSVNDFKAVRTIAVLIGSFTLSWSPFLITSIVQVACHKCCLYQVLEKYLWLLGVGNSLLNPLIYAYWQREVRQQLYHMALGVKKFFTSILLLLPARNRGPERTRESAYHIVTISHPELDG
UniProt	Q7TQP3
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5263
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL1771088
Molecular formula	C22H28ClN3O2S
IUPAC name	5-chloro-2-[4-[1-(4-methylsulfonylphenyl)piperidin-4-yl]piperidin-1-yl]pyridine
Molecular weight	433.995
Hydrogen bond acceptor	5
Hydrogen bond donor	0
XlogP	4.5
Synonyms	SCHEMBL10276517 1-(5-chloropyridin-2-yl)-1''-(4-(methylsulfonyl)phenyl)-4,4''-bipiperidine BDBM50342686
Inchi Key	CQGOOXRESMDIBQ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C22H28ClN3O2S/c1-29(27,28)21-5-3-20(4-6-21)25-12-8-17(9-13-25)18-10-14-26(15-11-18)22-7-2-19(23)16-24-22/h2-7,16-18H,8-15H2,1H3
PubChem CID	54580904
ChEMBL	CHEMBL1771088
IUPHAR	N/A
BindingDB	50342686
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	131.0 nM	PMID21273063	BindingDB,ChEMBL

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