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Name | Putative P2Y purinoceptor 10 |
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Species | Homo sapiens (Human) |
Gene | P2RY10 |
Synonym | P2Y-like receptor P2RY10 purinergic receptor P2Y purinergic receptor P2Y, G-protein coupled 10 purinergic receptor P2Y10 [ Show all ] |
Disease | N/A |
Length | 339 |
Amino acid sequence | MANLDKYTETFKMGSNSTSTAEIYCNVTNVKFQYSLYATTYILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLAHVLSLPLRIYYYISHHWPFQRALCLLCFYLKYLNMYASICFLTCISLQRCFFLLKPFRARDWKRRYDVGISAAIWIVVGTACLPFPILRSTDLNNNKSCFADLGYKQMNAVALVGMITVAELAGFVIPVIIIAWCTWKTTISLRQPPMAFQGISERQKALRMVFMCAAVFFICFTPYHINFIFYTMVKETIISSCPVVRIALYFHPFCLCLASLCCLLDPILYYFMASEFRDQLSRHGSSVTRSRLMSKESGSSMIG |
UniProt | O00398 |
Protein Data Bank | N/A |
GPCR-HGmod model | O00398 |
3D structure model | This predicted structure model is from GPCR-EXP O00398. |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL3562166 |
IUPHAR | 165 |
DrugBank | N/A |
Name | CHEMBL3577176 |
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Molecular formula | C30H52NO10P |
IUPAC name | (2S)-2-amino-3-[hydroxy-[(2R)-2-hydroxy-3-[3-(4-pentadecoxyphenyl)propanoyloxy]propoxy]phosphoryl]oxypropanoic acid |
Molecular weight | 617.717 |
Hydrogen bond acceptor | 11 |
Hydrogen bond donor | 4 |
XlogP | 3.7 |
Synonyms | BDBM50096443 |
Inchi Key | IBNSOXBZKPVHNZ-IAPPQJPRSA-N |
Inchi ID | InChI=1S/C30H52NO10P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-21-38-27-18-15-25(16-19-27)17-20-29(33)39-22-26(32)23-40-42(36,37)41-24-28(31)30(34)35/h15-16,18-19,26,28,32H,2-14,17,20-24,31H2,1H3,(H,34,35)(H,36,37)/t26-,28+/m1/s1 |
PubChem CID | 122177522 |
ChEMBL | CHEMBL3577176 |
IUPHAR | N/A |
BindingDB | 50096443 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand has more than 10 hydrogen bond acceptor. This ligand is heavier than 500 daltons. |
Parameter | Value | Reference | Database source |
---|---|---|---|
EC50 | 53.0 nM | PMID25970039 | BindingDB,ChEMBL |
EC50 | 53.7 nM | PMID25970039 | ChEMBL |
EC50 | 54.0 nM | PMID25970039 | BindingDB |
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