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GPCR

NamePutative P2Y purinoceptor 10
SpeciesHomo sapiens (Human)
GeneP2RY10
SynonymP2Y-like receptor
P2RY10
purinergic receptor P2Y
purinergic receptor P2Y, G-protein coupled 10
purinergic receptor P2Y10
[ Show all ]
DiseaseN/A
Length339
Amino acid sequenceMANLDKYTETFKMGSNSTSTAEIYCNVTNVKFQYSLYATTYILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLAHVLSLPLRIYYYISHHWPFQRALCLLCFYLKYLNMYASICFLTCISLQRCFFLLKPFRARDWKRRYDVGISAAIWIVVGTACLPFPILRSTDLNNNKSCFADLGYKQMNAVALVGMITVAELAGFVIPVIIIAWCTWKTTISLRQPPMAFQGISERQKALRMVFMCAAVFFICFTPYHINFIFYTMVKETIISSCPVVRIALYFHPFCLCLASLCCLLDPILYYFMASEFRDQLSRHGSSVTRSRLMSKESGSSMIG
UniProtO00398
Protein Data BankN/A
GPCR-HGmod modelO00398
3D structure modelThis predicted structure model is from GPCR-EXP O00398.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3562166
IUPHAR165
DrugBankN/A

Ligand

NameCHEMBL3577176
Molecular formulaC30H52NO10P
IUPAC name(2S)-2-amino-3-[hydroxy-[(2R)-2-hydroxy-3-[3-(4-pentadecoxyphenyl)propanoyloxy]propoxy]phosphoryl]oxypropanoic acid
Molecular weight617.717
Hydrogen bond acceptor11
Hydrogen bond donor4
XlogP3.7
SynonymsBDBM50096443
Inchi KeyIBNSOXBZKPVHNZ-IAPPQJPRSA-N
Inchi IDInChI=1S/C30H52NO10P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-21-38-27-18-15-25(16-19-27)17-20-29(33)39-22-26(32)23-40-42(36,37)41-24-28(31)30(34)35/h15-16,18-19,26,28,32H,2-14,17,20-24,31H2,1H3,(H,34,35)(H,36,37)/t26-,28+/m1/s1
PubChem CID122177522
ChEMBLCHEMBL3577176
IUPHARN/A
BindingDB50096443
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has more than 10 hydrogen bond acceptor.
This ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
EC5053.0 nMPMID25970039BindingDB,ChEMBL
EC5053.7 nMPMID25970039ChEMBL
EC5054.0 nMPMID25970039BindingDB

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