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GPCR

NameG-protein coupled receptor 35
SpeciesHomo sapiens (Human)
GeneGPR35
SynonymG-protein coupled receptor 3
GPR35
KYNA receptor
Kynurenic acid receptor
DiseaseN/A
Length309
Amino acid sequenceMNGTYNTCGSSDLTWPPAIKLGFYAYLGVLLVLGLLLNSLALWVFCCRMQQWTETRIYMTNLAVADLCLLCTLPFVLHSLRDTSDTPLCQLSQGIYLTNRYMSISLVTAIAVDRYVAVRHPLRARGLRSPRQAAAVCAVLWVLVIGSLVARWLLGIQEGGFCFRSTRHNFNSMAFPLLGFYLPLAVVVFCSLKVVTALAQRPPTDVGQAEATRKAARMVWANLLVFVVCFLPLHVGLTVRLAVGWNACALLETIRRALYITSKLSDANCCLDAICYYYMAKEFQEASALAVAPSAKAHKSQDSLCVTLA
UniProtQ9HC97
Protein Data BankN/A
GPCR-HGmod modelQ9HC97
3D structure modelThis predicted structure model is from GPCR-EXP Q9HC97.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL1293267
IUPHAR102
DrugBankBE0005562

Ligand

NameMLS000948484
Molecular formulaC24H25ClN4OS
IUPAC name5-[4-(dimethylamino)phenyl]-N-(2-methoxy-5-methylphenyl)-4-phenyl-1,3,4-thiadiazol-4-ium-2-amine;chloride
Molecular weight453.001
Hydrogen bond acceptor6
Hydrogen bond donor1
XlogPNone
SynonymsSR-01000829369-2
HMS2226H10
SMR000526900
HMS3338E14
SR-01000829369
[ Show all ]
Inchi KeyCPZDXTWYXRBRFK-UHFFFAOYSA-M
Inchi IDInChI=1S/C24H25N4OS.ClH/c1-17-10-15-22(29-4)21(16-17)25-24-26-28(20-8-6-5-7-9-20)23(30-24)18-11-13-19(14-12-18)27(2)3;/h5-16H,1-4H3,(H,25,26);1H/q+1;/p-1
PubChem CID24792181
ChEMBLCHEMBL1306983
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessPartition coefficient log P of this ligand is not available.

Experimental Data

ParameterValueReferenceDatabase source
IC503542.33 nMPubChem BioAssay data setChEMBL

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