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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	G-protein coupled receptor 183
Species	Homo sapiens (Human)
Gene	GPR183
Synonym	EBI2 {ECO:0000303\|PubMed:8383238} lymphocyte-specific G protein-coupled receptor hEBI2 {ECO:0000303\|PubMed:22875855} GPR183 G protein-coupled receptor 183 EBI2 Epstein-Barr virus-induced G-protein coupled receptor 2 {ECO:0000303\|PubMed:8383238} EBV-induced G-protein coupled receptor 2 {ECO:0000303\|PubMed:8383238} EBV-induced G protein-coupled receptor 2 Epstein-Barr virus-induced gene 2 [ Show all ]
Disease	N/A
Length	361
Amino acid sequence	MDIQMANNFTPPSATPQGNDCDLYAHHSTARIVMPLHYSLVFIIGLVGNLLALVVIVQNRKKINSTTLYSTNLVISDILFTTALPTRIAYYAMGFDWRIGDALCRITALVFYINTYAGVNFMTCLSIDRFIAVVHPLRYNKIKRIEHAKGVCIFVWILVFAQTLPLLINPMSKQEAERITCMEYPNFEETKSLPWILLGACFIGYVLPLIIILICYSQICCKLFRTAKQNPLTEKSGVNKKALNTIILIIVVFVLCFTPYHVAIIQHMIKKLRFSNFLECSQRHSFQISLHFTVCLMNFNCCMDPFIYFFACKGYKRKVMRMLKRQVSVSISSAVKSAPEENSREMTETQMMIHSKSSNGK
UniProt	P32249
Protein Data Bank	N/A
GPCR-HGmod model	P32249
3D structure model	This predicted structure model is from GPCR-EXP P32249.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3259470
IUPHAR	81
DrugBank	N/A

Ligand

Name	CHEMBL3560209
Molecular formula	C23H26Cl2N2O3S
IUPAC name	(E)-1-[4-(4-tert-butylphenyl)sulfonylpiperazin-1-yl]-3-(3,4-dichlorophenyl)prop-2-en-1-one
Molecular weight	481.432
Hydrogen bond acceptor	4
Hydrogen bond donor	0
XlogP	5.4
Synonyms	SCHEMBL17938677 MLS-0472717.0001 SCHEMBL17938674
Inchi Key	GSXBGDCSDRBXHR-VZUCSPMQSA-N
Inchi ID	InChI=1S/C23H26Cl2N2O3S/c1-23(2,3)18-6-8-19(9-7-18)31(29,30)27-14-12-26(13-15-27)22(28)11-5-17-4-10-20(24)21(25)16-17/h4-11,16H,12-15H2,1-3H3/b11-5+
PubChem CID	73330420
ChEMBL	CHEMBL3560209
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
IC50	46.8 nM	PubChem BioAssay data set	ChEMBL

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