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GPCR

NameMuscarinic acetylcholine receptor M2
SpeciesRattus norvegicus (Rat)
GeneChrm2
Synonymcholinergic receptor
cholinergic receptor, muscarinic 2
AChR M2
Chrm-2
M2 muscarinic acetylcholine receptor
[ Show all ]
DiseaseN/A for non-human GPCRs
Length466
Amino acid sequenceMNNSTNSSNNGLAITSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKEKKEPVANQDPVSPSLVQGRIVKPNNNNMPGGDGGLEHNKIQNGKAPRDGVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSRDDNSKQTCIKIVTKAQKGDVCTPTSTTVELVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
UniProtP10980
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL309
IUPHAR14
DrugBankN/A

Ligand

NameCHEMBL279135
Molecular formulaC19H22N4O2
IUPAC name11-[5-(dimethylamino)pentanoyl]-5H-pyrido[2,3-b][1,4]benzodiazepin-6-one
Molecular weight338.411
Hydrogen bond acceptor4
Hydrogen bond donor1
XlogP0.9
SynonymsBDBM50023651
11-(5-Dimethylamino-pentanoyl)-5,11-dihydro-benzo[e]pyrido[3,2-b][1,4]diazepin-6-one
Inchi KeyCPLCQZRQVPNBAT-UHFFFAOYSA-N
Inchi IDInChI=1S/C19H22N4O2/c1-22(2)13-6-5-11-17(24)23-16-10-4-3-8-14(16)19(25)21-15-9-7-12-20-18(15)23/h3-4,7-10,12H,5-6,11,13H2,1-2H3,(H,21,25)
PubChem CID14054137
ChEMBLCHEMBL279135
IUPHARN/A
BindingDB50023651
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC50500.0 nMPMID3373484BindingDB,ChEMBL

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