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Name | Free fatty acid receptor 2 |
---|---|
Species | Homo sapiens (Human) |
Gene | FFAR2 |
Synonym | FFA2R G protein-coupled receptor 43 G-protein coupled receptor 43 GPCR3 GPR43 [ Show all ] |
Disease | Abortion Diabetes |
Length | 330 |
Amino acid sequence | MLPDWKSSLILMAYIIIFLTGLPANLLALRAFVGRIRQPQPAPVHILLLSLTLADLLLLLLLPFKIIEAASNFRWYLPKVVCALTSFGFYSSIYCSTWLLAGISIERYLGVAFPVQYKLSRRPLYGVIAALVAWVMSFGHCTIVIIVQYLNTTEQVRSGNEITCYENFTDNQLDVVLPVRLELCLVLFFIPMAVTIFCYWRFVWIMLSQPLVGAQRRRRAVGLAVVTLLNFLVCFGPYNVSHLVGYHQRKSPWWRSIAVVFSSLNASLDPLLFYFSSSVVRRAFGRGLQVLRNQGSSLLGRRGKDTAEGTNEDRGVGQGEGMPSSDFTTE |
UniProt | O15552 |
Protein Data Bank | N/A |
GPCR-HGmod model | O15552 |
3D structure model | This predicted structure model is from GPCR-EXP O15552. |
BioLiP | N/A |
Therapeutic Target Database | T28213 |
ChEMBL | CHEMBL5493 |
IUPHAR | 226 |
DrugBank | N/A |
Name | CHEMBL611339 |
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Molecular formula | C14H14Cl2N2OS |
IUPAC name | (2S)-2-(4-chlorophenyl)-N-(5-chloro-1,3-thiazol-2-yl)-3-methylbutanamide |
Molecular weight | 329.239 |
Hydrogen bond acceptor | 3 |
Hydrogen bond donor | 1 |
XlogP | 5.0 |
Synonyms | BDBM50305981 (S)-2-(4-chlorophenyl)-N-(5-chlorothiazol-2-yl)-3-methylbutanamide |
Inchi Key | CPDXIHHGJDEMTJ-LBPRGKRZSA-N |
Inchi ID | InChI=1S/C14H14Cl2N2OS/c1-8(2)12(9-3-5-10(15)6-4-9)13(19)18-14-17-7-11(16)20-14/h3-8,12H,1-2H3,(H,17,18,19)/t12-/m0/s1 |
PubChem CID | 46226253 |
ChEMBL | CHEMBL611339 |
IUPHAR | N/A |
BindingDB | 50305981 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Efficacy | 100.0 % | PMID20005104 | ChEMBL |
IC50 | 700.0 nM | PMID20005104 | BindingDB,ChEMBL |
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