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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	G-protein coupled receptor 35
Species	Homo sapiens (Human)
Gene	GPR35
Synonym	G-protein coupled receptor 3 GPR35 KYNA receptor Kynurenic acid receptor
Disease	N/A
Length	309
Amino acid sequence	MNGTYNTCGSSDLTWPPAIKLGFYAYLGVLLVLGLLLNSLALWVFCCRMQQWTETRIYMTNLAVADLCLLCTLPFVLHSLRDTSDTPLCQLSQGIYLTNRYMSISLVTAIAVDRYVAVRHPLRARGLRSPRQAAAVCAVLWVLVIGSLVARWLLGIQEGGFCFRSTRHNFNSMAFPLLGFYLPLAVVVFCSLKVVTALAQRPPTDVGQAEATRKAARMVWANLLVFVVCFLPLHVGLTVRLAVGWNACALLETIRRALYITSKLSDANCCLDAICYYYMAKEFQEASALAVAPSAKAHKSQDSLCVTLA
UniProt	Q9HC97
Protein Data Bank	N/A
GPCR-HGmod model	Q9HC97
3D structure model	This predicted structure model is from GPCR-EXP Q9HC97.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL1293267
IUPHAR	102
DrugBank	BE0005562

Ligand

Name	CHEMBL2392175
Molecular formula	C19H14BrNO6
IUPAC name	6-bromo-8-[(4-ethoxybenzoyl)amino]-4-oxochromene-2-carboxylic acid
Molecular weight	432.226
Hydrogen bond acceptor	6
Hydrogen bond donor	2
XlogP	3.1
Synonyms	BDBM50436019
Inchi Key	COWMNPYZUXTPOK-UHFFFAOYSA-N
Inchi ID	InChI=1S/C19H14BrNO6/c1-2-26-12-5-3-10(4-6-12)18(23)21-14-8-11(20)7-13-15(22)9-16(19(24)25)27-17(13)14/h3-9H,2H2,1H3,(H,21,23)(H,24,25)
PubChem CID	71733844
ChEMBL	CHEMBL2392175
IUPHAR	N/A
BindingDB	50436019
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	634.0 nM	PMID23713606	BindingDB,ChEMBL
Emax	99.0 %	PMID23713606	ChEMBL
Ki	98.0 nM	PMID23888932	BindingDB
Ki	98.4 nM	PMID23888932	ChEMBL

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