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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	D(3) dopamine receptor
Species	Homo sapiens (Human)
Gene	DRD3
Synonym	dopaminergic receptor D3 D3R D3 receptor dopamine D3 receptor
Disease	Unspecified Emesis; Gastric motility disorder Female sexual dysfunction Male sexual disorders Psychotic disorders Cocaine addiction Schizophrenia Drug abuse [ Show all ]
Length	400
Amino acid sequence	MASLSQLSSHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC
UniProt	P35462
Protein Data Bank	3pbl
GPCR-HGmod model	P35462
3D structure model	This structure is from PDB ID 3pbl.
BioLiP	BL0191566, BL0191567
Therapeutic Target Database	T02551
ChEMBL	CHEMBL234
IUPHAR	216
DrugBank	BE0000581

Ligand

Name	MLS000106452
Molecular formula	C17H24FN3O
IUPAC name	1-[4-[4-(2-fluorophenyl)piperazin-1-yl]piperidin-1-yl]ethanone
Molecular weight	305.397
Hydrogen bond acceptor	4
Hydrogen bond donor	0
XlogP	2.0
Synonyms	SR-01000208151 HMS2441C20 1-[4-[4-(2-fluorophenyl)piperazino]piperidino]ethanone BDBM38235 Oprea1_549991 CHEMBL1721257 SR-01000208151-1 1-[4-[4-(2-fluorophenyl)-1-piperazinyl]-1-piperidinyl]ethanone Cambridge id 5410004 SMR000103419 cid_743199 SR-01000208151-3 1-[4-[4-(2-fluorophenyl)piperazin-1-yl]piperidin-1-yl]ethanone MolPort-045-968-224 AC1LEWVF [ Show all ]
Inchi Key	DGZHDCOAURPHLR-UHFFFAOYSA-N
Inchi ID	InChI=1S/C17H24FN3O/c1-14(22)19-8-6-15(7-9-19)20-10-12-21(13-11-20)17-5-3-2-4-16(17)18/h2-5,15H,6-13H2,1H3
PubChem CID	743199
ChEMBL	CHEMBL1721257
IUPHAR	N/A
BindingDB	38235
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Potency	2511.9 nM	PubChem BioAssay data set	ChEMBL

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