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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	D(3) dopamine receptor
Species	Homo sapiens (Human)
Gene	DRD3
Synonym	dopaminergic receptor D3 D3R D3 receptor dopamine D3 receptor
Disease	Unspecified Emesis; Gastric motility disorder Female sexual dysfunction Male sexual disorders Psychotic disorders Cocaine addiction Schizophrenia Drug abuse [ Show all ]
Length	400
Amino acid sequence	MASLSQLSSHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC
UniProt	P35462
Protein Data Bank	3pbl
GPCR-HGmod model	P35462
3D structure model	This structure is from PDB ID 3pbl.
BioLiP	BL0191566, BL0191567
Therapeutic Target Database	T02551
ChEMBL	CHEMBL234
IUPHAR	216
DrugBank	BE0000581

Ligand

Name	SMR000102164
Molecular formula	C15H17FN4
IUPAC name	2-[4-[(3-fluorophenyl)methyl]piperazin-1-yl]pyrimidine
Molecular weight	272.327
Hydrogen bond acceptor	5
Hydrogen bond donor	0
XlogP	2.1
Synonyms	AC1LG0ZS HMS2395N03 SR-01000201904-3 2-[4-[(3-fluorophenyl)methyl]piperazin-1-yl]pyrimidine Cambridge id 5262831 MolPort-002-141-014 414880-94-7 CHEMBL1531923 SR-01000201904 2-[4-(3-fluorobenzyl)piperazino]pyrimidine AKOS003971138 MCULE-8057217717 Z46210756 2-{4-[(3-fluorophenyl)methyl]piperazin-1-yl}pyrimidine CHEBI:116368 Oprea1_287217 AB00077583-01 cid_763417 SR-01000201904-1 2-[4-[(3-fluorophenyl)methyl]-1-piperazinyl]pyrimidine BDBM38726 MLS000105283 ZINC19536766 [ Show all ]
Inchi Key	DDFZWZOMOJAGID-UHFFFAOYSA-N
Inchi ID	InChI=1S/C15H17FN4/c16-14-4-1-3-13(11-14)12-19-7-9-20(10-8-19)15-17-5-2-6-18-15/h1-6,11H,7-10,12H2
PubChem CID	763417
ChEMBL	CHEMBL1531923
IUPHAR	N/A
BindingDB	38726
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Potency	1000.0 nM	PubChem BioAssay data set	ChEMBL

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