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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	G-protein coupled receptor 183
Species	Homo sapiens (Human)
Gene	GPR183
Synonym	EBI2 {ECO:0000303\|PubMed:8383238} lymphocyte-specific G protein-coupled receptor hEBI2 {ECO:0000303\|PubMed:22875855} GPR183 G protein-coupled receptor 183 EBI2 Epstein-Barr virus-induced G-protein coupled receptor 2 {ECO:0000303\|PubMed:8383238} EBV-induced G-protein coupled receptor 2 {ECO:0000303\|PubMed:8383238} EBV-induced G protein-coupled receptor 2 Epstein-Barr virus-induced gene 2 [ Show all ]
Disease	N/A
Length	361
Amino acid sequence	MDIQMANNFTPPSATPQGNDCDLYAHHSTARIVMPLHYSLVFIIGLVGNLLALVVIVQNRKKINSTTLYSTNLVISDILFTTALPTRIAYYAMGFDWRIGDALCRITALVFYINTYAGVNFMTCLSIDRFIAVVHPLRYNKIKRIEHAKGVCIFVWILVFAQTLPLLINPMSKQEAERITCMEYPNFEETKSLPWILLGACFIGYVLPLIIILICYSQICCKLFRTAKQNPLTEKSGVNKKALNTIILIIVVFVLCFTPYHVAIIQHMIKKLRFSNFLECSQRHSFQISLHFTVCLMNFNCCMDPFIYFFACKGYKRKVMRMLKRQVSVSISSAVKSAPEENSREMTETQMMIHSKSSNGK
UniProt	P32249
Protein Data Bank	N/A
GPCR-HGmod model	P32249
3D structure model	This predicted structure model is from GPCR-EXP P32249.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3259470
IUPHAR	81
DrugBank	N/A

Ligand

Name	CHEMBL3559896
Molecular formula	C19H17Br2FN2O3S
IUPAC name	(E)-3-(4-bromo-2-fluorophenyl)-1-[4-(4-bromophenyl)sulfonylpiperazin-1-yl]prop-2-en-1-one
Molecular weight	532.222
Hydrogen bond acceptor	5
Hydrogen bond donor	0
XlogP	3.9
Synonyms	SBI-0646693.0001 SCHEMBL16599171 SCHEMBL16599173
Inchi Key	CWGRRTLCUWHDLB-KRXBUXKQSA-N
Inchi ID	InChI=1S/C19H17Br2FN2O3S/c20-15-4-6-17(7-5-15)28(26,27)24-11-9-23(10-12-24)19(25)8-2-14-1-3-16(21)13-18(14)22/h1-8,13H,9-12H2/b8-2+
PubChem CID	73330400
ChEMBL	CHEMBL3559896
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
IC50	65.5 nM	PubChem BioAssay data set	ChEMBL

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