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Name | Histamine H4 receptor |
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Species | Rattus norvegicus (Rat) |
Gene | Hrh4 |
Synonym | GPCR105 H4 receptor H4R HH4R |
Disease | N/A for non-human GPCRs |
Length | 391 |
Amino acid sequence | MSESNGTDVLPLTAQVPLAFLMSLLAFAITIGNAVVILAFVADRNLRHRSNYFFLNLAISDFFVGVISIPLYIPHTLFNWNFGSGICMFWLITDYLLCTASVYSIVLISYDRYQSVSNAVRYRAQHTGILKIVAQMVAVWILAFLVNGPMILASDSWKNSTNTEECEPGFVTEWYILAITAFLEFLLPVSLVVYFSVQIYWSLWKRGSLSRCPSHAGFIATSSRGTGHSRRTGLACRTSLPGLKEPAASLHSESPRGKSSLLVSLRTHMSGSIIAFKVGSFCRSESPVLHQREHVELLRGRKLARSLAVLLSAFAICWAPYCLFTIVLSTYRRGERPKSIWYSIAFWLQWFNSLINPFLYPLCHRRFQKAFWKILCVTKQPAPSQTQSVSS |
UniProt | Q91ZY1 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL4468 |
IUPHAR | 265 |
DrugBank | N/A |
Name | JNJ-39758979 |
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Molecular formula | C11H19N5 |
IUPAC name | 4-[(3R)-3-aminopyrrolidin-1-yl]-6-propan-2-ylpyrimidin-2-amine |
Molecular weight | 221.308 |
Hydrogen bond acceptor | 5 |
Hydrogen bond donor | 2 |
XlogP | 0.7 |
Synonyms | JNJ 39758979 UNII-5RV7T5BNMG 1046447-90-8 JNL-39758979 GTPL8984 [ Show all ] |
Inchi Key | COOGVHJHSCBOQT-MRVPVSSYSA-N |
Inchi ID | InChI=1S/C11H19N5/c1-7(2)9-5-10(15-11(13)14-9)16-4-3-8(12)6-16/h5,7-8H,3-4,6,12H2,1-2H3,(H2,13,14,15)/t8-/m1/s1 |
PubChem CID | 24994634 |
ChEMBL | CHEMBL3236549 |
IUPHAR | 8984 |
BindingDB | 50006789 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Kd | 63.1 nM | PMID24495018 | ChEMBL |
Ki | 188.0 nM | PMID24495018, PMID25993395 | BindingDB,ChEMBL |
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