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Name | Sphingosine 1-phosphate receptor 2 |
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Species | Homo sapiens (Human) |
Gene | S1PR2 |
Synonym | Endothelial differentiation G-protein coupled receptor 5 Sphingosine 1-phosphate receptor Edg-5 S1P2 receptor S1P2 S1P receptor Edg-5 [ Show all ] |
Disease | Hypertension |
Length | 353 |
Amino acid sequence | MGSLYSEYLNPNKVQEHYNYTKETLETQETTSRQVASAFIVILCCAIVVENLLVLIAVARNSKFHSAMYLFLGNLAASDLLAGVAFVANTLLSGSVTLRLTPVQWFAREGSAFITLSASVFSLLAIAIERHVAIAKVKLYGSDKSCRMLLLIGASWLISLVLGGLPILGWNCLGHLEACSTVLPLYAKHYVLCVVTIFSIILLAIVALYVRIYCVVRSSHADMAAPQTLALLKTVTIVLGVFIVCWLPAFSILLLDYACPVHSCPILYKAHYFFAVSTLNSLLNPVIYTWRSRDLRREVLRPLQCWRPGVGVQGRRRGGTPGHHLLPLRSSSSLERGMHMPTSPTFLEGNTVV |
UniProt | O95136 |
Protein Data Bank | N/A |
GPCR-HGmod model | O95136 |
3D structure model | This predicted structure model is from GPCR-EXP O95136. |
BioLiP | N/A |
Therapeutic Target Database | T47888 |
ChEMBL | CHEMBL2955 |
IUPHAR | 276 |
DrugBank | N/A |
Name | CHEMBL3703200 |
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Molecular formula | C36H44FN3O6 |
IUPAC name | 4-(2-ethylbutyl)-N-[3-(4-fluorophenoxy)-5-[4-(3-hydroxypiperidine-1-carbonyl)phenoxy]phenyl]-4-hydroxypiperidine-1-carboxamide |
Molecular weight | 633.761 |
Hydrogen bond acceptor | 7 |
Hydrogen bond donor | 3 |
XlogP | 6.1 |
Synonyms | US8975409, Example 15(6) BDBM149708 SCHEMBL14839327 |
Inchi Key | BZVBOQNGUPRKHW-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C36H44FN3O6/c1-3-25(4-2)23-36(44)15-18-39(19-16-36)35(43)38-28-20-32(22-33(21-28)46-31-13-9-27(37)10-14-31)45-30-11-7-26(8-12-30)34(42)40-17-5-6-29(41)24-40/h7-14,20-22,25,29,41,44H,3-6,15-19,23-24H2,1-2H3,(H,38,43) |
PubChem CID | 89484784 |
ChEMBL | CHEMBL3703200 |
IUPHAR | N/A |
BindingDB | 149708 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | 5.1 nM | , None | BindingDB,ChEMBL |
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