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Name | Sphingosine 1-phosphate receptor 2 |
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Species | Rattus norvegicus (Rat) |
Gene | S1pr2 |
Synonym | S1P2 receptor S1P2 S1P receptor Edg-5 S1P receptor 2 GPCR18 [ Show all ] |
Disease | N/A for non-human GPCRs |
Length | 352 |
Amino acid sequence | MGGLYSEYLNPEKVQEHYNYTKETLDMQETPSRKVASAFIIILCCAIVVENLLVLIAVARNSKFHSAMYLFLGNLAASDLLAGVAFVANTLLSGPVTLSLTPLQWFAREGSAFITLSASVFSLLAIAIERQVAIAKVKLYGSDKSCRMLMLIGASWLISLILGGLPILGWNCLDHLEACSTVLPLYAKHYVLCVVTIFSVILLAIVALYVRIYFVVRSSHADVAGPQTLALLKTVTIVLGVFIICWLPAFSILLLDSTCPVRACPVLYKAHYFFAFATLNSLLNPVIYTWRSRDLRREVLRPLLCWRQGKGATGRRGGNPGHRLLPLRSSSSLERGLHMPTSPTFLEGNTVV |
UniProt | P47752 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL3616360 |
IUPHAR | 276 |
DrugBank | N/A |
Name | CHEMBL3703198 |
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Molecular formula | C34H39FN2O6 |
IUPAC name | 1-[4-[3-[[4-(2-ethylbutyl)-4-hydroxypiperidine-1-carbonyl]amino]-5-(4-fluorophenoxy)phenoxy]phenyl]cyclopropane-1-carboxylic acid |
Molecular weight | 590.692 |
Hydrogen bond acceptor | 7 |
Hydrogen bond donor | 3 |
XlogP | 6.5 |
Synonyms | BDBM149706 SCHEMBL14839321 US8975409, Example 13 |
Inchi Key | UZPSRIVFHKJDOL-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C34H39FN2O6/c1-3-23(4-2)22-33(41)15-17-37(18-16-33)32(40)36-26-19-29(21-30(20-26)43-28-11-7-25(35)8-12-28)42-27-9-5-24(6-10-27)34(13-14-34)31(38)39/h5-12,19-21,23,41H,3-4,13-18,22H2,1-2H3,(H,36,40)(H,38,39) |
PubChem CID | 89484778 |
ChEMBL | CHEMBL3703198 |
IUPHAR | N/A |
BindingDB | 149706 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | 3.0 nM | , None | BindingDB,ChEMBL |
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