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GPCR

Name	Alpha-2A adrenergic receptor
Species	Mus musculus (Mouse)
Gene	Adra2a
Synonym	alpha2D alpha2A-AR alpha2A-adrenoceptor alpha2A-adrenergic receptor alpha2A Alpha-2AAR Alpha-2A adrenoreceptor Alpha-2A adrenoceptor adrenergic receptor Adrenergic alpha 2A receptor ADRA2R ADRA2 Adra-2a Adra-2 [ Show all ]
Disease	N/A for non-human GPCRs
Length	450
Amino acid sequence	MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGPTGAEAEPLPTQLNGAPGEPAPAGPRDGDALDLEESSSSEHAERPPGPRRPDRGPRAKGKTRASQVKPGDSLPRRGPGAAGPGASGSGHGEERGGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPSQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV
UniProt	Q01338
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4075
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	naphazoline
Molecular formula	C14H14N2
IUPAC name	2-(naphthalen-1-ylmethyl)-4,5-dihydro-1H-imidazole
Molecular weight	210.28
Hydrogen bond acceptor	1
Hydrogen bond donor	1
XlogP	2.1
Synonyms	NCGC00016506-02 AK-968/41090774 Prestwick3_000046 BRD-K77641333-003-05-7 Spectrum2_001054 CC-32429 UNII-H231GF11BV Clearine Enamine_000333 Imidin KBioGR_000595 2-(1-Naphthylmethyl)-2-imidazoline Nafazolin 2-Imidazoline, 2-(1-naphthylmethyl)- Naphazoline Monohydrochloride 835-31-4 NCGC00016506-05 AN-47765 Sanorin (Salt/Mix) BRN 0151864 Spectrum5_001424 CHEMBL1706 D0O6IZ H231GF11BV KBio1_000456 .alpha.-Naphthylmethyl imidazoline LS-79666 2-(alpha-Naphthylmethyl)-imidazoline Nafazolina [DCIT] 4,5-Dihydro-2-(1-naphthylmethyl)imidazole Naphazolinum [INN-Latin] AB00053505-12 AC1L1I5Y Prestwick1_000046 BDBM50001922 SPBio_001008 C-23907 STK300042 Ciba 2020/R DivK1c_000456 IDI1_000456 KBio2_006591 2-(1-Naphthalenylmethyl)-2-imidazoline Nadaplatin 2-(Naphthyl-(1')-methyl)imidazolin [German] 550-99-2 (mono-hydrochloride) Naphthizine NCGC00016506-03 AKOS000295230 Privine (Salt/Mix) BRD-K77641333-003-15-6 Spectrum3_000513 CCG-250339 Z56762888 CNIIGCLFLJGOGP-UHFFFAOYSA-N FT-0725973 K490 KBioSS_001455 2-(1-Naphthylmethyl)-4,5-dihydro-1H-imidazole Nafazolin (TN) 2-Naphthalen-1-ylmethyl-4,5-dihydro-1H-imidazole; hydrochloride Naphazoline [INN:BAN] A840596 AB00053505_13 NINDS_000456 Antan SBI-0051454.P003 BSPBio_000171 Spectrum_000975 HMS1394P03 KBio2_001455 1H-Imidazole, 4,5-dihydro-2-(1-naphthalenylmethyl)- MCULE-9097339235 2-(naphthalen-1-ylmethyl)-4,5-dihydro-1H-imidazole Nafazoline 5-23-08-00293 (Beilstein Handbook Reference) Naphazolinum [Latin] AJ-11616 Prestwick2_000046 BPBio1_000189 SPBio_002092 C14H14N2 T8212 cid_11079 EINECS 212-641-5 IMI033 KBio3_001565 2-(1-naphthalenylmethyl)-4,5-dihydro-1H-imidazole NAFAZAIR 2-(naphthylmethyl)-2-imidazoline Naphazoline (INN) 550N992 NCGC00016506-01 NCGC00016506-04 alpha-Naphthylmethyl imidazoline Rhinazine BRD-K77641333-003-25-5 Spectrum4_000068 CHEBI:93363 ZINC119717 D08253 GTPL5509 KB-224262 L000878 2-(1-Naphthylmethyl)-4,5-dihydro-1H-imidazole # Nafazolina 2-[(naphthalen-1-yl)methyl]-4,5-dihydro-1H-imidazole Naphazolinum AB00053505-11 AB00053505_14 Prestwick0_000046 BBL012612 SCHEMBL34532 BSPBio_002065 ST45061546 CHEMBL761 DB06711 HMS2090D15 KBio2_004023 2-(.alpha.-Naphthylmethyl)-imidazoline MolPort-001-641-043 2-(Naphthyl-(1')-methyl)imidazolin Nafazoline [Spanish] Naphcon [ Show all ]
Inchi Key	CNIIGCLFLJGOGP-UHFFFAOYSA-N
Inchi ID	InChI=1S/C14H14N2/c1-2-7-13-11(4-1)5-3-6-12(13)10-14-15-8-9-16-14/h1-7H,8-10H2,(H,15,16)
PubChem CID	4436
ChEMBL	CHEMBL761
IUPHAR	N/A
BindingDB	50001922
DrugBank	DB06711
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	11.48 nM	PMID9605427	BindingDB
Ki	16.98 nM	PMID9605427	BindingDB

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