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GLASS

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GPCR

Name	Glucagon receptor
Species	Homo sapiens (Human)
Gene	GCGR
Synonym	GL-R GGR GR glucagon receptor
Disease	Diabetes Type 2 diabetes Non-insulin dependent diabetes Obesity; Diabetes Type 1 diabetes Hypoglycemia [ Show all ]
Length	477
Amino acid sequence	MPPCQPQRPLLLLLLLLACQPQVPSAQVMDFLFEKWKLYGDQCHHNLSLLPPPTELVCNRTFDKYSCWPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPDGQWVRGPRGQPWRDASQCQMDGEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTRNAIHANLFASFVLKASSVLVIDGLLRTRYSQKIGDDLSVSTWLSDGAVAGCRVAAVFMQYGIVANYCWLLVEGLYLHNLLGLATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQCWTSNDNMGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTDYKFRLAKSTLTLIPLLGVHEVVFAFVTDEHAQGTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRLGKVLWEERNTSNHRASSSPGHGPPSKELQFGRGGGSQDSSAETPLAGGLPRLAESPF
UniProt	P47871
Protein Data Bank	5yqz, 5xez, 5ee7, 5xf1
GPCR-HGmod model	P47871
3D structure model	This structure is from PDB ID 5yqz.
BioLiP	BL0379634,BL0379635, BL0402227, BL0379636,BL0379637, BL0343437
Therapeutic Target Database	T60182, T87875
ChEMBL	CHEMBL1985
IUPHAR	251
DrugBank	N/A

Ligand

Name	CHEMBL3675813
Molecular formula	C29H25Cl2N3O3
IUPAC name	3-[[5-[5-chloro-2-[[4-(4-chlorophenyl)-N-methylanilino]methyl]phenyl]pyridine-2-carbonyl]amino]propanoic acid
Molecular weight	534.437
Hydrogen bond acceptor	5
Hydrogen bond donor	2
XlogP	6.1
Synonyms	3-(5-(5-chloro-2-(((4'-chloro-[1,1'-biphenyl]-4-yl)(methyl)amino)methyl)phenyl)picolinamido)propanoic acid US8748624, 17 BBQZOEDRERJFHQ-UHFFFAOYSA-N BDBM123532 SCHEMBL14055616
Inchi Key	BBQZOEDRERJFHQ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C29H25Cl2N3O3/c1-34(25-11-5-20(6-12-25)19-2-8-23(30)9-3-19)18-22-4-10-24(31)16-26(22)21-7-13-27(33-17-21)29(37)32-15-14-28(35)36/h2-13,16-17H,14-15,18H2,1H3,(H,32,37)(H,35,36)
PubChem CID	71060099
ChEMBL	CHEMBL3675813
IUPHAR	N/A
BindingDB	123532
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
Ki	1478.1 nM	, None	BindingDB,ChEMBL

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