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GPCR

Name	Neuromedin-U receptor 2
Species	Homo sapiens (Human)
Gene	NMUR2
Synonym	G-protein coupled receptor FM-4 G-protein coupled receptor TGR-1 FM4 NMU-R2 NMU2 receptor FM-4 SNORF72 TGR-1 [ Show all ]
Disease	N/A
Length	415
Amino acid sequence	MSGMEKLQNASWIYQQKLEDPFQKHLNSTEEYLAFLCGPRRSHFFLPVSVVYVPIFVVGVIGNVLVCLVILQHQAMKTPTNYYLFSLAVSDLLVLLLGMPLEVYEMWRNYPFLFGPVGCYFKTALFETVCFASILSITTVSVERYVAILHPFRAKLQSTRRRALRILGIVWGFSVLFSLPNTSIHGIKFHYFPNGSLVPGSATCTVIKPMWIYNFIIQVTSFLFYLLPMTVISVLYYLMALRLKKDKSLEADEGNANIQRPCRKSVNKMLFVLVLVFAICWAPFHIDRLFFSFVEEWSESLAAVFNLVHVVSGVFFYLSSAVNPIIYNLLSRRFQAAFQNVISSFHKQWHSQHDPQLPPAQRNIFLTECHFVELTEDIGPQFPCQSSMHNSHLPAALSSEQMSRTNYQSFHFNKT
UniProt	Q9GZQ4
Protein Data Bank	N/A
GPCR-HGmod model	Q9GZQ4
3D structure model	This predicted structure model is from GPCR-EXP Q9GZQ4.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL1075144
IUPHAR	299
DrugBank	N/A

Ligand

Name	Synephrine
Molecular formula	C9H13NO2
IUPAC name	4-[1-hydroxy-2-(methylamino)ethyl]phenol
Molecular weight	167.208
Hydrogen bond acceptor	3
Hydrogen bond donor	3
XlogP	-0.6
Synonyms	DTXSID0030588 (RS)-1-(4-Hydroxyphenyl)-2-(methylamino)ethanol HMS2052G09 1-(4-Hydroxyphenyl)-N-methylethanolamine HMS3715I18 4-[1-Hydroxy-2-(methylamino)ethyl]phenol Lopac0_001085 AB00384265_11 MLS001424216 alpha-(4-Oxyphenyl)alpha-oxy-beta-methylaminoaethan NCGC00015924-08 Benzenemethanol, 4-hydroxy-alpha-((methylamino)methyl)- NCGC00258515-01 BENZYL ALCOHOL, p-HYDROXY-alpha-((METHYLAMINO)METHYL)-, (-)- NSC170956 CC-34623 CTK2F4574 (+,-)-Synephrine p-Hydroxy-alpha-((methylamino)methyl)benzyl alcohol Parakorper Prestwick1_001088 s2362 SMR000059111 SW197214-5 Tox21_110390_1 [(Methylamino)methyl][(4-hydroxyphenyl)carbinol] EU-0101085 1-(4-Hydroxyphenyl)-(2-methylamino)ethanol HMS3263I12 4-Hydroxy-.alpha.-((methylamino)methyl)benzenemethanol I06-0007 582-84-3 LS-43029 AC1Q412W NC00348 API0024621 NCGC00015924-13 Benzenemethanol, 4-hydroxy-alpha-((methylamino)methyl)-, (S)- NSC 170956 BPBio1_001250 Oxedrine ((-)-) CHEBI:29081 DB09203 (+/-)-Synephrine, >=98% p-Hydroxyphenylmethylaminoethanol PDSP1_000167 Q-100668 SBI-0051055.P002 SR-01000002983-3 Sympathol Synephrine, analytical standard TR-038493 Oxedrine, p-Synephrine, Sympatol, Parasympatol, Sympaethamine, 34520 (.+/-.)-Synephrine FT-0653012 1-(4-Hydroxyphenyl)-2-(methylamino)ethanol HMS3394G09 4-Hydroxy-alpha-(methylaminomethyl)benzyl alcohol l-Sympatol 94S075 Methylaminomethyl(4-hydroxyphenyl)carbinol AKOS016038542 NCGC00015924-05 BDBM50102660 NCGC00089788-03 BENZYL ALCOHOL, p-HYDROXY-alpha-((METHYLAMINO)METHYL)- NSC-759316 C04548 Oxedrine [INN:BAN] CPD000059111 ((Methylamino)methyl)((4-hydroxyphenyl)carbinol) DSSTox_GSID_30588 p-Hydroxy-.alpha.-[(methylamino)methyl]benzyl alcohol p-Synephrine Pharmakon1600-01506085 S 38537-9 Simpalon ST095769 Synefrin [Czech] T5534 YRCWQPVGYLYSOX-UHFFFAOYSA-N EINECS 202-300-9 (y)-Synephrine HMS2098I18 1-[4-Hydroxyphenyl]-2-methylaminoethanol I01-2279 4-[1-Hydroxy-2-(methylamino)ethyl]phenol # LP01085 AB00514040 MolPort-000-787-358 alpha-(4-Oxyphenyl)alpha-oxy-beta-methylaminoaethan [German] NCGC00015924-09 Benzenemethanol, 4-hydroxy-alpha-((methylamino)methyl)- (9CI) NCGC00261770-01 beta-Methylamino-alpha-(4-hydroxyphenyl)ethyl alcohol NSC759316 CCG-101098 D07148 (+-)-N-Methyloctopamine p-Hydroxy-alpha-[(methylamino)methyl]benzyl alcohol Parakorper [German] Prestwick2_001088 SAM001246896 SPBio_003028 Sympaethamin Synephrine (Oxedrine) Tox21_200962 FCH1116446 1-(4-Hydroxyphenyl)-(N-methylethanol)amine HMS3264E11 4-Hydroxy-a-(methylaminomethyl)benzyl alcohol K712 7336264B-EDC9-42C5-939B-FF800AB5BB4A LS-43031 AK141733 NCGC00015924-03 AX8011379 NCGC00016351-01 benzenemethanol, 4-hydroxy-alpha-[(methylamino)methyl]-, 2,3-dihydroxybutanedioate (1:1) (salt) NSC-166285 BSPBio_001136 Oxedrine (BAN) ( inverted exclamation markA)-Synephrine DL-SYNEPHRINE (+/-)synephrine p-Methylaminoethanolphenol PDSP2_000166 RP23020 SC-46736 SR-01000002983-7 Sympatol Synephrine,(S) W-100214 Oxedrine\|\|\|4-Hydroxy-a-[(methylamino)methyl]-benzenemethanol (?)-Synephrine HMS1571I18 1-(4-Hydroxyphenyl)-2-methylaminoethanol HMS3656O09 4-hydroxy-alpha-[(methylamino)methyl]benzenemethanol l-Synephrine AB0014348 MLS000069435 ALBB-025740 NCGC00015924-06 Benzenemethanol, 4-hydroxy-.alpha.-[(methylamino)methyl]- NCGC00089788-04 BENZYL ALCOHOL, p-HYDROXY-alpha-((METHYLAMINO)METHYL)-, (+)- NSC166285 CAS-94-07-5 CS0043 (+)-[(methylamino)methyl]-Benzenemethano DSSTox_RID_78850 p-Hydroxy-.alpha.-[(methylamino)methyl]benzylalcohol p-[(Methylamino)ethanol]phenol Prestwick0_001088 S0232 Simpatol STK803113 Synephrin Tox21_110390 ZX-AN024253 Ethaphene .beta.-Methylamino-.alpha.-(4-hydroxyphenyl)ethyl alcohol HMS2233F20 4-(1-Hydroxy-2-(methylamino)ethyl)phenol I01-8196 LS-43028 AC1L1O67 N1706 Analeptin NCGC00015924-12 Benzenemethanol, 4-hydroxy-alpha-((methylamino)methyl)-, (-)- NSC 166285 BP-12742 Oxedrine CCG-205162 (+/-)-Synephrine p-Hydroxyphenyl(methylamino)ethanol Parasympatol Prestwick3_001088 SBB063601 SR-01000002983 Sympaethamine Synephrine - Oxedrine Tox21_501085 (.+/-.)-N-Methyloctopamine FT-0618685 1-(4-hydroxyphenyl)-2-(methylamino)ethan-1-ol HMS3369C13 4-Hydroxy-alpha-((methylamino)methyl)benzenemethanol KS-5152 94-07-5 MCULE-4991429316 AKOS004119915 NCGC00015924-04 BBL015111 NCGC00089788-02 Benzyl alcohol, p-hydroxy-.alpha.-[(methylamino)methyl]- NSC-170956 C-33457 Oxedrine [BAN] CHEMBL33720 ( inverted question mark)-Synephrine DSSTox_CID_10588 p-((Methylamino)ethanol)phenol p-Oxedrine Pentedrin [German] S 0752 SCHEMBL146500 SR-01000002983-8 Synefrin Synthenate WLN: QR DYQ1M1 [ Show all ]
Inchi Key	YRCWQPVGYLYSOX-UHFFFAOYSA-N
Inchi ID	InChI=1S/C9H13NO2/c1-10-6-9(12)7-2-4-8(11)5-3-7/h2-5,9-12H,6H2,1H3
PubChem CID	7172
ChEMBL	CHEMBL33720
IUPHAR	N/A
BindingDB	50102660
DrugBank	DB09203
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	6600.0 nM	PMID25262941	BindingDB,ChEMBL

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