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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Lysophosphatidic acid receptor 4
Species	Mus musculus (Mouse)
Gene	Lpar4
Synonym	P2Y9 P2Y5-like receptor P2Y purinoceptor 9 P2RY9 LPA4 receptor LPA4 LPA-4 LPA receptor 4 GPR23 G-protein coupled receptor 23 G protein-coupled receptor 23 Purinergic receptor 9 [ Show all ]
Disease	N/A for non-human GPCRs
Length	370
Amino acid sequence	MGDRRFIDFQFQDLNSSLRPRLGNATANNTCIVDDSFKYNLNGAVYSVVFILGLITNSASLFVFCFRMKMRSETAIFITNLALSDLLFVCTLPFKIFYNFNRHWPFGDTLCKISGTAFLTNIYGSMLFLTCISVDRFLAIVYPFRSRTIRTRRNSAIVCAGVWILVLSGGISASLFSTTNVNNATTTCFEGFSKRVWKTYLSKITIFIEVVGFIIPLILNVSCSSVVLRTLRKPATLSQIGTNKKKVLKMITVHMAVFVVCFVPYNSVLFLYALVRSQAITNCLLERFAKIMYPITLCLATLNCCFDPFIYYFTLESFQKSFYINTHIRMESLFKTETPLTPKPSLPAIQEEVSDQTTNNGGELMLESTF
UniProt	Q8BLG2
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3321650
IUPHAR	94
DrugBank	N/A

Ligand

Name	1-Oleoyl Lysophosphatidic Acid
Molecular formula	C21H41O7P
IUPAC name	[(2R)-2-hydroxy-3-phosphonooxypropyl] (Z)-octadec-9-enoate
Molecular weight	436.526
Hydrogen bond acceptor	7
Hydrogen bond donor	3
XlogP	5.2
Synonyms	1-oleylglycerol 3-phosphate AC1NSKBQ HMS1791G08 LPA(18:1n9/0:0) Lysophosphatidic acid(18:1n9/0:0) PA(18:1(9Z)/0:0) [(2R)-2-hydroxy-3-phosphonooxypropyl] (Z)-octadec-9-enoate 18:1 LPA C21H41O7P IDI1_033876 LysoPA(18:1) Monooleylphosphatidic acid SR-01000946335 (R)-Octadec-9-enoic acid 2-hydroxy-3-phosphonooxy-propyl ester 1-Oleoyl-sn-glycero-3-phosphate 1-oleyl-2-lyso-sn-glycerol 3-phosphatidic acid 9-Octadecenoic acid (9Z)-, 2-hydroxy-3-(phosphonooxy)propyl ester CHEMBL117021 LPA(18:1(9Z)/0:0) Lysophosphatidic acid(18:1) NCGC00161386-03 WRGQSWVCFNIUNZ-GDCKJWNLSA-N 1-O-oleoyl-sn-glycerol 3-phosphate 1-Oleyllysophosphatidic acid BDBM50148348 HMS1989G08 LPA(18:1w9/0:0) Lysophosphatidic acid(18:1w9/0:0) PA(18:1/0:0) (2r)-2-Hydroxy-3-(Phosphonooxy)propyl (9e)-Octadec-9-Enoate 1-oleoyl-2-lyso-sn-glycerol 3-phosphatidic acid CHEBI:62837 LMGP10050008 LysoPA(18:1w9/0:0) NCGC00161386-01 SR-01000946335-1 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate 1-Oleoyl-sn-glycerol 3-phosphate 1-oleyl-sn-glycerol 3-phosphate 9-Octadecenoic acid (Z)-, 2-hydroxy-3-(phosphonooxy)propyl ester, (R)- Epitope ID:158640 LPA(18:1/0:0) Lysophosphatidic acid(18:1/0:0) NKP ZINC8860530 1-O-oleyl-sn-glycerol 3-phosphate 1293AH BSPBio_001406 HMS3650F05 LysoPA(18:1(9Z)/0:0) MolPort-009-019-282 SCHEMBL1560791 (2R)-2-hydroxy-3-(phosphonooxy)propyl (9Z)-octadec-9-enoate 1-Oleoyl-L-.alpha.-lysophosphatidic acid 65528-98-5 LPA 18:1 lysophosphatidic acid NCGC00161386-02 UNII-PG6M3969SG component WRGQSWVCFNIUNZ-GDCKJWNLSA-N 1-O-9Z-Octadecenoyl-sn-glyceryl-3-phosphoric acid 1-oleoylglycerol 3-phosphate [ Show all ]
Inchi Key	WRGQSWVCFNIUNZ-GDCKJWNLSA-N
Inchi ID	InChI=1S/C21H41O7P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-21(23)27-18-20(22)19-28-29(24,25)26/h9-10,20,22H,2-8,11-19H2,1H3,(H2,24,25,26)/b10-9-/t20-/m1/s1
PubChem CID	5311263
ChEMBL	CHEMBL117021
IUPHAR	N/A
BindingDB	50148348
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
EC50	260.0 nM	PMID25100502	BindingDB,ChEMBL

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