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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Sphingosine 1-phosphate receptor 2
Species	Homo sapiens (Human)
Gene	S1PR2
Synonym	Endothelial differentiation G-protein coupled receptor 5 Sphingosine 1-phosphate receptor Edg-5 S1P2 receptor S1P2 S1P receptor Edg-5 S1P receptor 2 edg5 endothelial differentiation G protein-coupled receptor 5 GPCR18 Gpcr13 G protein-coupled receptor 13 [ Show all ]
Disease	Hypertension
Length	353
Amino acid sequence	MGSLYSEYLNPNKVQEHYNYTKETLETQETTSRQVASAFIVILCCAIVVENLLVLIAVARNSKFHSAMYLFLGNLAASDLLAGVAFVANTLLSGSVTLRLTPVQWFAREGSAFITLSASVFSLLAIAIERHVAIAKVKLYGSDKSCRMLLLIGASWLISLVLGGLPILGWNCLGHLEACSTVLPLYAKHYVLCVVTIFSIILLAIVALYVRIYCVVRSSHADMAAPQTLALLKTVTIVLGVFIVCWLPAFSILLLDYACPVHSCPILYKAHYFFAVSTLNSLLNPVIYTWRSRDLRREVLRPLQCWRPGVGVQGRRRGGTPGHHLLPLRSSSSLERGMHMPTSPTFLEGNTVV
UniProt	O95136
Protein Data Bank	N/A
GPCR-HGmod model	O95136
3D structure model	This predicted structure model is from GPCR-EXP O95136.
BioLiP	N/A
Therapeutic Target Database	T47888
ChEMBL	CHEMBL2955
IUPHAR	276
DrugBank	N/A

Ligand

Name	SR-02000000239
Molecular formula	C19H16ClNO2
IUPAC name	5-(3-chlorophenyl)-N-(2,6-dimethylphenyl)furan-2-carboxamide
Molecular weight	325.792
Hydrogen bond acceptor	2
Hydrogen bond donor	1
XlogP	5.2
Synonyms	BDBM62395 SR-02000000239-1 5-(3-chlorophenyl)-N-(2,6-dimethylphenyl)-2-furancarboxamide cid_878124 AC1LGWV4 Oprea1_850793 ZINC447531 5-(3-chlorophenyl)-N-(2,6-dimethylphenyl)furan-2-carboxamide MCULE-2028466521 AKOS002709427 5-(3-chlorophenyl)-N-(2,6-dimethylphenyl)-2-furamide CHEMBL1354080 MolPort-000-227-236 [ Show all ]
Inchi Key	CMIVNSUOASYQSC-UHFFFAOYSA-N
Inchi ID	InChI=1S/C19H16ClNO2/c1-12-5-3-6-13(2)18(12)21-19(22)17-10-9-16(23-17)14-7-4-8-15(20)11-14/h3-11H,1-2H3,(H,21,22)
PubChem CID	878124
ChEMBL	CHEMBL1354080
IUPHAR	N/A
BindingDB	62395
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
IC50	<25000.0 nM	, PubChem BioAssay data set	BindingDB,ChEMBL

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